tbjournalТуберкулез и социально значимые заболеванияTuberculosis and socially significant diseases2413-03462413-0354ООО «Ин-Тренд10.54921/2413-0346-2023-11-4-30-38tbjournal-105Research ArticleЛАБОРАТОРНАЯ ДИАГНОСТИКАLABORATORY DIAGNOSTICSМолекулярные тест-системы гибридизационного анализа в диагностике лекарственной чувствительности M. tuberculosis к фторхинолонам и инъекционным препаратамMolecular tests for hybridization analysis in the diagnosis of drug susceptibility of M. Tuberculosis to fluoroquinolones and injectable drugsИсаковаА. И.IsakovaA. I.

Исакова Александра Ивановна – врач клинической лабораторной диагностики Централизованной бактериологической лаборатории

107014, Москва, ул. Стромынка, д. 10

Moscow

isakovaaleks@gmail.comМихайловаЮ. Д.MikhailovaYu. D.

Михайлова Юлия Дмитриевна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, кандидат биологических наук

107014, Москва, ул. Стромынка, д. 10

Moscow

juliaisaeva81@rambler.ruСвириденкоМ. А.SviridenkoM. A.

Свириденко Мария Александровна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, кандидат медицинских наук

107014, Москва, ул. Стромынка, д. 10

Moscow

dna77@mail.ruХахалинаА. А.KhakhalinaA. A.

Хахалина Анастасия Александровна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, кандидат биологических наук

107014, Москва, ул. Стромынка, д. 10

Moscow

nastec@bk.ruГалкинаК. Ю.GalkinaK. Yu.

Галкина Ксения Юрьевна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, кандидат биологических наук

107014, Москва, ул. Стромынка, д. 10

Moscow

crazymare@mail.ruНосоваЕ. Ю.NosovaE. Yu.

Носова Елена Юрьевна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, доктор медицинских наук

107014, Москва, ул. Стромынка, д. 10

Moscow

rna68@rambler.ruСафоноваС. Г.SafonovaS. G.

Сафонова Светлана Григорьевна – заведующая отделом проблем лабораторной диагностики туберкулеза и патоморфологии, доктор биологических наук 

107014, Москва, ул. Стромынка, д. 10

Moscow

safonova.s.g@inbox.ruГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»РоссияThe Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of HealthRussian Federation2023301220231143038Copyright © Исакова А.И., Михайлова Ю.Д., Свириденко М.А., Хахалина А.А., Галкина К.Ю., Носова Е.Ю., Сафонова С.Г., 20232023Исакова А.И., Михайлова Ю.Д., Свириденко М.А., Хахалина А.А., Галкина К.Ю., Носова Е.Ю., Сафонова С.Г.Isakova A.I., Mikhailova Y.D., Sviridenko M.A., Khakhalina A.A., Galkina K.Y., Nosova E.Y., Safonova S.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tb-journal.ru/jour/article/view/105

В работе представлены данные тестирования лекарственной чувствительности (ЛЧ) клинических изолятов M. tuberculosis к фторхинолонам и инъекционным препаратам с помощью молекулярно-генетических тест-систем и фенотипических методов. Показаны диагностические возможности гибридизационных технологий «ТБ-ТЕСТ» и GenoType MTBDRsl v.2 в определении генетических детерминант устойчивости изолятов с множественной, пре-широкой и широкой лекарственной устойчивостью.

The paper presents data on testing the drug susceptibility of clinical isolates of M. tuberculosis (MTB) to fluoroquinolones and injectable drugs using molecular genetic tests and phenotypic methods. We demonstrated the diagnostic capabilities of the hybridization technologies «TB-TEST and GenoType MTBDRsl v.2 to detect the genetic determinants of resistance in MTB isolates with multidrug and extensively drug resistance (MDR, XDR), as well as in MBT with pre-XDR.

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The authors declare that there are no conflicts of interest present.