tbjournalТуберкулез и социально значимые заболеванияTuberculosis and socially significant diseases2413-03462413-0354ООО «Ин-Тренд10.54921/2413-0346-2024-12-1-30-35tbjournal-134Research ArticleЛАБОРАТОРНЫЕ ИССЛЕДОВАНИЯ В ЛЕЧЕНИИ ТУБЕРКУЛЕЗА И СОЧЕТАННЫХ ИНФЕКЦИЙLABORATORY STUDIES IN THE TREATMENT OF TUBERCULOSIS AND COMBINED INFECTIONSИзучение активности бедаквилина in vitro в отношении Mycobacterium fortuitum complexIn vitro activity of bedaquiline against Mycobacterium fortuitum complexhttps://orcid.org/0000-0002-2686-0952МакароваМ. В.MakarovaM. V.

Макарова Марина Витальевна – главный научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, доктор биологических наук

107014, г. Москва, ул. Стромынка, д. 10, стр. 1

Тел. +7 (495) 603-30-33

makarova75@yandex.ruhttps://orcid.org/0000-0001-6849-0702МихайловаЮ. Д.MikhailovaY. D.

Михайлова Юлия Дмитриевна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, кандидат биологических наук

107014, г. Москва, ул. Стромынка, д. 10, стр. 1

Тел. + 7 (495) 603-30-33

juliaisaeva81@rambler.ruСвириденкоМ. А.SviridenkoM. A.

Свириденко Мария Александровна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, кандидат биологических наук

107014, г. Москва, ул. Стромынка, д. 10, стр. 1

Тел. +7 (495) 603-30-33

dna77@mail.ruhttps://orcid.org/0000-0002-9125-5038ХачатурьянцЕ. Н.KhachaturyantsE. N.

Хачатурьянц Елена Николаевна – врач-бактериолог Централизованной бактериологической лаборатории, кандидат биологических наук

107014, г. Москва, ул. Стромынка, д. 10, стр. 1

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hen65b@mail.ruhttps://orcid.org/0000-0002-5335-7690ЛитвиновВ. И.LitvinovV. I.

Литвинов Виталий Ильич – научный руководитель, доктор медицинских наук, профессор, академик РАН

107014, г. Москва, ул. Стромынка, д. 10, стр. 1

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mnpcbtlv@yandex.ruГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»РоссияMoscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Health Department (MRCCTC)Russian Federation2024300320241213035Copyright © Макарова М.В., Михайлова Ю.Д., Свириденко М.А., Хачатурьянц Е.Н., Литвинов В.И., 20242024Макарова М.В., Михайлова Ю.Д., Свириденко М.А., Хачатурьянц Е.Н., Литвинов В.И.Makarova M.V., Mikhailova Y.D., Sviridenko M.A., Khachaturyants E.N., Litvinov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tb-journal.ru/jour/article/view/134

Изучена активность бедаквилина (Bdq) – препарата, который эффективно используется для лечения туберкулеза, в том числе с множественной (МЛУ) и широкой лекарственной устойчивостью (ШЛУ) возбудителя, в отношении быстрорастущих нетуберкулезных микобактерий (НТМБ), принадлежащих Mycobacterium fortuitum complex (MFC).Материал и методы. Исследовано 154 культуры MFC (78 – M. fortuitum и 76 – M. peregrinum). С помощью тест-системы Sensititre RapMyco изучена лекарственная чувствительность (ЛЧ) этих штаммов к 15 антибактериальным препаратам (АБП).Результаты. Диапазон МИК Bdq в отношении M. fortuitum был установлен в интервале 0,0015–1,0 мкг/мл, M. peregrinum – 0,0015–2,0 мкг/мл. МИК50 для M. fortuitum составил 0,015 мкг/мл, МИК90 – 0,25 мкг/мл, ECOFF – 0,5 мкг/мл. Для M. peregrinum соответствующие показатели составили 0,007, 0,06 и 2,0 мкг/мл. В итоге был обнаружен лишь 1 (1,3%) устойчивый штамм M. fortuitum; устойчивых штаммов M. peregrinum не обнаружено. При изучении ЛЧ к другим АБП выявлена высокая степень устойчивости M. fortuitum и M. peregrinum к большинству из них.Заключение. Установлено, что Bdq активен в отношении MFC in vitro и с большой вероятностью будет эффективен в химиотерапии микобактериозов, вызванных этими видами НТМБ.

The activity of bedaquiline (Bdq), a drug that is effectively used for the treatment of tuberculosis, including those with multiple (MDR) and extensively drug resistant (XDR) pathogen, was studied against rapidly growing non-tuberculous mycobacteria (NTM) belonging to Mycobacterium fortuitum complex (MFC).Methods. А total 154 strains of MFC (78 of M. fortuitum and 76 of M. peregrinum) were examined. In addition, the drug susceptibility (DS) of these strains to 15 antibacterial drugs (ABD) was studied using the Sensitititre RapMyco test system.Results. Тhe Bdq MIC range for M. fortuitum was found to be 0.0015–1.0 μg/mL, M. peregrinum – 0.0015–2.0 μg/mL. The MIC50 for M. fortuitum was 0.015 µg/mL, MIC90 was 0.25 µg/mL, and ECOFF was 0.5 µg/mL. For M. peregrinum, the corresponding values were 0.007, 0.06 and 2.0 µg/mL. As a result, only 1 (1.3%) resistant strain of M. fortuitum was detected, no resistant strains of M. peregrinum were found. When the DS of these NTM species to other ABDs were studied, it was found that M. fortuitum and M. peregrinum were highly resistant to most of them.Conclusion. Bdq was found to be active against MFC in vitro and is likely to be effective in the chemotherapy of mycobacteriosis caused by these NTM species.

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The authors declare that there are no conflicts of interest present.