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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tbjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Туберкулез и социально значимые заболевания</journal-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis and socially significant diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2413-0346</issn><issn pub-type="epub">2413-0354</issn><publisher><publisher-name>ООО «Ин-Тренд</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.54921/2413-0346-2021-12-2-70-82</article-id><article-id custom-type="elpub" pub-id-type="custom">tbjournal-21</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>Проблемы лекарственной устойчивости M. tuberculosis</article-title><trans-title-group xml:lang="en"><trans-title>Problems of drug resistance of M. tuberculosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвинов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Litvinov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Литвинов Виталий Ильич – научный руководитель, доктор медицинских наук, профессор, академик РАН </p><p>107014, г. Москва, ул. Стромынка, д. 10</p></bio><email xlink:type="simple">mnpcbtlv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Носова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Nosova</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Носова Елена Юрьевна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии, кандидат медицинских наук</p><p>107014, г. Москва, ул. Стромынка, д. 10</p></bio><email xlink:type="simple">rna68@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2021</year></pub-date><volume>9</volume><issue>2</issue><fpage>70</fpage><lpage>82</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Литвинов В.И., Носова Е.Ю., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Литвинов В.И., Носова Е.Ю.</copyright-holder><copyright-holder xml:lang="en">Litvinov V.I., Nosova E.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tb-journal.ru/jour/article/view/21">https://www.tb-journal.ru/jour/article/view/21</self-uri><abstract><p>В обзоре литературы представлены новейшие сведения о механизмах развития лекарственной устойчивости M. tuberculosis и методах исследования лекарственной чувствительности микобактерий</p></abstract><trans-abstract xml:lang="en"><p>The review presents the latest information on the mechanisms of development of drug resistance of M. tuberculosis and methods for studying the drug sensitivity of mycobacteria</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Противотуберкулезная работа в городе Москве. Аналитический обзор статистических показателей по туберкулезу, 2018 г. / Под ред. Е.М. Богородской, В.И. Литвинова, Е.М. Белиловского. – М.: МНПЦБТ, 2019. – 216 с.</mixed-citation><mixed-citation xml:lang="en">Противотуберкулезная работа в городе Москве. Аналитический обзор статистических показателей по туберкулезу, 2018 г. / Под ред. Е.М. Богородской, В.И. Литвинова, Е.М. Белиловского. – М.: МНПЦБТ, 2019. – 216 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Борисов С.Е., Белиловский Е.М., Данилова И.Д., Рыбка Л.Н. Туберкулез с множественной лекарственной устойчивостью возбудителя // Противотуберкулезная работа в городе Москве. Аналитический обзор статистических показателей по туберкулезу, 2018 г. / Под ред. Е.М. Богородской, В.И. Литвинова, Е.М. Белиловского. – М.: МНПЦБТ, 2019. – С. 95-105.</mixed-citation><mixed-citation xml:lang="en">Борисов С.Е., Белиловский Е.М., Данилова И.Д., Рыбка Л.Н. Туберкулез с множественной лекарственной устойчивостью возбудителя // Противотуберкулезная работа в городе Москве. Аналитический обзор статистических показателей по туберкулезу, 2018 г. / Под ред. Е.М. Богородской, В.И. Литвинова, Е.М. Белиловского. – М.: МНПЦБТ, 2019. – С. 95-105.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева И.А., Белиловский Е.М., Борисов С.Е., Стерликов С.А. Туберкулез с множественной лекарственной устойчивостью возбудителя в странах мира и в Российской Федерации // Туберкулез и болезни легких. – 2017. – Т. 95. – № 11. – С. 5-18.</mixed-citation><mixed-citation xml:lang="en">Васильева И.А., Белиловский Е.М., Борисов С.Е., Стерликов С.А. Туберкулез с множественной лекарственной устойчивостью возбудителя в странах мира и в Российской Федерации // Туберкулез и болезни легких. – 2017. – Т. 95. – № 11. – С. 5-18.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Исаева Е.Л. Генетические мутации микобактерии туберкулеза, ответственные за резистентность к рифампицину у больных туберкулезом: идентификация и характеристика: Дисс. ... канд. мед. наук. – М., 2002. – 103 с.</mixed-citation><mixed-citation xml:lang="en">Исаева Е.Л. Генетические мутации микобактерии туберкулеза, ответственные за резистентность к рифампицину у больных туберкулезом: идентификация и характеристика: Дисс. ... канд. мед. наук. – М., 2002. – 103 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Клиническая фармакокинетика: теоретические, прикладные и аналитические аспекты: руководство / Под ред. В.Г. Кукеса. – М.: ГЭОТАР-Медиа, 2009. – 2009. – 432 с.</mixed-citation><mixed-citation xml:lang="en">Клиническая фармакокинетика: теоретические, прикладные и аналитические аспекты: руководство / Под ред. В.Г. Кукеса. – М.: ГЭОТАР-Медиа, 2009. – 2009. – 432 с.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Лабораторные исследования при туберкулезе / Под ред. В.И. Литвинова, А.М. Мороза. – М.: МНПЦБТ, 2013. – 342 с.</mixed-citation><mixed-citation xml:lang="en">Лабораторные исследования при туберкулезе / Под ред. В.И. Литвинова, А.М. Мороза. – М.: МНПЦБТ, 2013. – 342 с.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Макарова М.В., Крылова Л.Ю., Носова Е.Ю., Литвинов В.И. Характеристика штаммов M. tuberculosis с широкой лекарственной устойчивостью с помощью тест-системы Sensititre MycoTB (предпосылки для внесения корректив в лечение больных туберкулезом с широкой лекарственной устойчивостью возбудителя) // Туберкулез и социально значимые заболевания. – 2016. – № 2. – С. 38-43.</mixed-citation><mixed-citation xml:lang="en">Макарова М.В., Крылова Л.Ю., Носова Е.Ю., Литвинов В.И. Характеристика штаммов M. tuberculosis с широкой лекарственной устойчивостью с помощью тест-системы Sensititre MycoTB (предпосылки для внесения корректив в лечение больных туберкулезом с широкой лекарственной устойчивостью возбудителя) // Туберкулез и социально значимые заболевания. – 2016. – № 2. – С. 38-43.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Мирзабеков А.Д. Биочипы в биологии и медицине XXΙ века // Вестник РАН. – 2003. – Т. 73. – № 5. – С. 412.</mixed-citation><mixed-citation xml:lang="en">Мирзабеков А.Д. Биочипы в биологии и медицине XXΙ века // Вестник РАН. – 2003. – Т. 73. – № 5. – С. 412.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Михайлова Ю.Д., Макарова М.В., Кудлай Д.А., Перетокина И.В., Сафонова С.Г., Литвинова Н.В., Крылова Л.Ю. Количественная оценка чувствительности Mycobacterium tuberculosis к линезолиду // Туберкулез и социально значимые заболевания. – 2019. – № 1. – С. 19-24.</mixed-citation><mixed-citation xml:lang="en">Михайлова Ю.Д., Макарова М.В., Кудлай Д.А., Перетокина И.В., Сафонова С.Г., Литвинова Н.В., Крылова Л.Ю. Количественная оценка чувствительности Mycobacterium tuberculosis к линезолиду // Туберкулез и социально значимые заболевания. – 2019. – № 1. – С. 19-24.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Носова Е.Ю., Галкина К.Ю., Антонова О.В., Гармаш Ю.Ю., Скотникова О.И., Мороз А.М. Молекулярно-биологический микрочип «ТБ-БИОЧИП-2» для определения чувствительности Mycobacterium tuberculosis с множественной лекарственной устойчивостью к фторхинолонам у больных с впервые выявленным и хроническим течением туберкулеза // Вестник РАМН. – 2008. – № 3. – С. 16-19.</mixed-citation><mixed-citation xml:lang="en">Носова Е.Ю., Галкина К.Ю., Антонова О.В., Гармаш Ю.Ю., Скотникова О.И., Мороз А.М. Молекулярно-биологический микрочип «ТБ-БИОЧИП-2» для определения чувствительности Mycobacterium tuberculosis с множественной лекарственной устойчивостью к фторхинолонам у больных с впервые выявленным и хроническим течением туберкулеза // Вестник РАМН. – 2008. – № 3. – С. 16-19.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Носова Е.Ю., Хахалина А.А., Исакова А.И., Галкина К.Ю., Краснова М.А., Макарова М.В. Одновременное определение генетических детерминант широкой лекарственной устойчивости и генотипирование M. tuberculosis с помощью гибридизационного анализа на биочипах // Туберкулез и социально значимые заболевания. – 2016. – № 2. – С. 24-32.</mixed-citation><mixed-citation xml:lang="en">Носова Е.Ю., Хахалина А.А., Исакова А.И., Галкина К.Ю., Краснова М.А., Макарова М.В. Одновременное определение генетических детерминант широкой лекарственной устойчивости и генотипирование M. tuberculosis с помощью гибридизационного анализа на биочипах // Туберкулез и социально значимые заболевания. – 2016. – № 2. – С. 24-32.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Перетокина И.В., Крылова Л.Ю., Сафонова С.Г., Макарова М.В., Носова Е.Ю., Литвинов В.И. Определение пограничного значения минимальной ингибирующей концентрации бедаквилина в отношении чувствительных клинических штаммов Mycobacterium tuberculosis на разных питательных средах // Туберкулез и социально значимые заболевания. – 2018. – № 3. – С. 32-35.</mixed-citation><mixed-citation xml:lang="en">Перетокина И.В., Крылова Л.Ю., Сафонова С.Г., Макарова М.В., Носова Е.Ю., Литвинов В.И. Определение пограничного значения минимальной ингибирующей концентрации бедаквилина в отношении чувствительных клинических штаммов Mycobacterium tuberculosis на разных питательных средах // Туберкулез и социально значимые заболевания. – 2018. – № 3. – С. 32-35.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Перетокина И.В., Крылова Л.Ю., Михайлова Ю.Д., Сафонова С.Г., Макарова М.В. Определение минимальных ингибирующих концентраций бедаквилина для оценки лекарственной чувствительности микобактерий туберкулеза // Туберкулез и болезни легких. – 2019. – Т. 97. – № 6. – С. 64-65.</mixed-citation><mixed-citation xml:lang="en">Перетокина И.В., Крылова Л.Ю., Михайлова Ю.Д., Сафонова С.Г., Макарова М.В. Определение минимальных ингибирующих концентраций бедаквилина для оценки лекарственной чувствительности микобактерий туберкулеза // Туберкулез и болезни легких. – 2019. – Т. 97. – № 6. – С. 64-65.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Скотникова О.И. Применение новых молекулярно-биологических технологий для выявления Mycobacterium tuberculosis с множественной лекарственной устойчивостью: Дисс. ... док. биол. наук. – М., 2008. – 215 с.</mixed-citation><mixed-citation xml:lang="en">Скотникова О.И. Применение новых молекулярно-биологических технологий для выявления Mycobacterium tuberculosis с множественной лекарственной устойчивостью: Дисс. ... док. биол. наук. – М., 2008. – 215 с.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Черноусова Л.Н., Андреевская С.Н., Смирнова Т.Г., Ларионова Е.Е., Ивахненко О.И., Новоселова Е.А., Шевкун Н.А. Лекарственно-устойчивый туберкулез: перспективы ускоренной диагностики и химиотерапии // Бактериология. – 2017. – № 1. – С. 25-34.</mixed-citation><mixed-citation xml:lang="en">Черноусова Л.Н., Андреевская С.Н., Смирнова Т.Г., Ларионова Е.Е., Ивахненко О.И., Новоселова Е.А., Шевкун Н.А. Лекарственно-устойчивый туберкулез: перспективы ускоренной диагностики и химиотерапии // Бактериология. – 2017. – № 1. – С. 25-34.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmad N., Javaid A., Sulaiman S., Ming L., Ahmad I., Khan A. Resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients // Braz. J. Infect. Dis. – 2016. – Vol. 20. – N. 1. – P. 41-47. doi: 10.1016/j.bjid.2015.09.011.</mixed-citation><mixed-citation xml:lang="en">Ahmad N., Javaid A., Sulaiman S., Ming L., Ahmad I., Khan A. Resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients // Braz. J. Infect. Dis. – 2016. – Vol. 20. – N. 1. – P. 41-47. doi: 10.1016/j.bjid.2015.09.011.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmad S., Jaber A., Mokaddas E. Frequency of embB codon 306 mutations in ethambutol-susceptible and -resistant clinical Mycobacterium tuberculosis isolates in Kuwait // Tuberculosis (Edinb.). – 2007. – Vol. 87. – P. 123-129.</mixed-citation><mixed-citation xml:lang="en">Ahmad S., Jaber A., Mokaddas E. Frequency of embB codon 306 mutations in ethambutol-susceptible and -resistant clinical Mycobacterium tuberculosis isolates in Kuwait // Tuberculosis (Edinb.). – 2007. – Vol. 87. – P. 123-129.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Alcaide F., Esteban J., González-Martin J., Palacios J. Methods for determining the antimicrobial susceptibility of mycobacteria // Enferm. Infecc. Microbiol. Clin. – 2017. – Vol. 35. – N. 8. – P. 529-535. doi: 10.1016/j.eimc.2016.04.008.</mixed-citation><mixed-citation xml:lang="en">Alcaide F., Esteban J., González-Martin J., Palacios J. Methods for determining the antimicrobial susceptibility of mycobacteria // Enferm. Infecc. Microbiol. Clin. – 2017. – Vol. 35. – N. 8. – P. 529-535. doi: 10.1016/j.eimc.2016.04.008.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Alsultan A., Savic R., Dooley K. et al. Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis // Antimicrob. Agents. Chemother. – 2017. – Vol. 61. – N. 6: e02625-16. doi:10.1128/AAC.02625-1.</mixed-citation><mixed-citation xml:lang="en">Alsultan A., Savic R., Dooley K. et al. Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis // Antimicrob. Agents. Chemother. – 2017. – Vol. 61. – N. 6: e02625-16. doi:10.1128/AAC.02625-1.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Andries K., Villellas C., Coeck N., Thys K., Gevers T., Vranckx L. et al. Acquired resistance of Mycobacterium tuberculosis to bedaquiline // PLoS One. – 2014. – Vol. 9. – N. 7: e102135. doi: 10.1371/journal.pone.0102135.</mixed-citation><mixed-citation xml:lang="en">Andries K., Villellas C., Coeck N., Thys K., Gevers T., Vranckx L. et al. Acquired resistance of Mycobacterium tuberculosis to bedaquiline // PLoS One. – 2014. – Vol. 9. – N. 7: e102135. doi: 10.1371/journal.pone.0102135.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Asín-Prieto E., Rodríguez-Gascón A., Isla A. Applications of the pharmacokinetic/pharmacodynamic (PK/PD) analysis of antimicrobial agents // J. Infect. Chemother. – 2015. – Vol. 21. – N. 5. – P. 319-329. doi: 10.1016/j.jiac.2015.02.001.</mixed-citation><mixed-citation xml:lang="en">Asín-Prieto E., Rodríguez-Gascón A., Isla A. Applications of the pharmacokinetic/pharmacodynamic (PK/PD) analysis of antimicrobial agents // J. Infect. Chemother. – 2015. – Vol. 21. – N. 5. – P. 319-329. doi: 10.1016/j.jiac.2015.02.001.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Bahuguna A., Rawat D. An overview of new antitubercular drugs, drug candidates, and their targets // Med. Res. Rev. – 2020. – Vol. 40. – N. 1. – P. 263‐292. doi:10.1002/med.21602.</mixed-citation><mixed-citation xml:lang="en">Bahuguna A., Rawat D. An overview of new antitubercular drugs, drug candidates, and their targets // Med. Res. Rev. – 2020. – Vol. 40. – N. 1. – P. 263‐292. doi:10.1002/med.21602.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Beckert P., Hillemann D., Kohl T., Kalinowski J., Richter E., Niemann S. et al. rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains // Antimicrob. Agents. Chemother. – 2012. – Vol. 56. – P. 2743-2745.</mixed-citation><mixed-citation xml:lang="en">Beckert P., Hillemann D., Kohl T., Kalinowski J., Richter E., Niemann S. et al. rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains // Antimicrob. Agents. Chemother. – 2012. – Vol. 56. – P. 2743-2745.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Blair H., Scott L. Delamanid: a review of its use in patients with multidrug-resistant tuberculosis // Drugs. – 2015. – Vol. 75. – N. 1. – P. 91‐100. doi:10.1007/s40265-014-0331-4.</mixed-citation><mixed-citation xml:lang="en">Blair H., Scott L. Delamanid: a review of its use in patients with multidrug-resistant tuberculosis // Drugs. – 2015. – Vol. 75. – N. 1. – P. 91‐100. doi:10.1007/s40265-014-0331-4.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Borah P., Deb P., Venugopala K., Al-Shari N., Singh V., Deka S. et al. Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-tb drugs, treatment regimens and host-directed therapies // Curr. Top. Med. Chem. – 2020. – Dec 11. doi: 10.2174/1568026621999201211200447.</mixed-citation><mixed-citation xml:lang="en">Borah P., Deb P., Venugopala K., Al-Shari N., Singh V., Deka S. et al. Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-tb drugs, treatment regimens and host-directed therapies // Curr. Top. Med. Chem. – 2020. – Dec 11. doi: 10.2174/1568026621999201211200447.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Borisov S., Dheda K., Enwerem M., Romero Leyet R., D’Ambrosio L., Centis R. et al. Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicenter study // Eur. Respir. J. – 2017. – Vol. 49. – N. 5:1700387. doi: 10.1183/13993003.00387-2017.</mixed-citation><mixed-citation xml:lang="en">Borisov S., Dheda K., Enwerem M., Romero Leyet R., D’Ambrosio L., Centis R. et al. Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicenter study // Eur. Respir. J. – 2017. – Vol. 49. – N. 5:1700387. doi: 10.1183/13993003.00387-2017.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Borrell S., Gagneux S. Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosis // Int. J. Tuberc. Lung Dis. – 2009. – Vol. 13. – P. 1456-1466.</mixed-citation><mixed-citation xml:lang="en">Borrell S., Gagneux S. Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosis // Int. J. Tuberc. Lung Dis. – 2009. – Vol. 13. – P. 1456-1466.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Brennan P., Nikaido H. The envelope of mycobacteria // Ann. Rev. Biochem. – 1995. – Vol. 64. – P. 29-63.</mixed-citation><mixed-citation xml:lang="en">Brennan P., Nikaido H. The envelope of mycobacteria // Ann. Rev. Biochem. – 1995. – Vol. 64. – P. 29-63.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Burian J., Ramón-García S., Sweet G., Gómez-Velasco A., Av-Gay Y., Thompson C. The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance // J. Biol. Chem. – 2012. – Vol. 287. – P. 299-310.</mixed-citation><mixed-citation xml:lang="en">Burian J., Ramón-García S., Sweet G., Gómez-Velasco A., Av-Gay Y., Thompson C. The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance // J. Biol. Chem. – 2012. – Vol. 287. – P. 299-310.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Chakravorty S., Lee J., Cho E., Roh S., Smith L., Lee J. et al. Genotypic susceptibility testing of Mycobacterium tuberculosis isolates for amikacin and kanamycin resistance by use of a rapid sloppy molecular beacon-based assay identifies more cases of low-level drug resistance than phenotypic Lowenstein-Jensen testing // J. Clin. Microbiol. – 2015. – Vol. 53. – N. 1. – P.43-51.</mixed-citation><mixed-citation xml:lang="en">Chakravorty S., Lee J., Cho E., Roh S., Smith L., Lee J. et al. Genotypic susceptibility testing of Mycobacterium tuberculosis isolates for amikacin and kanamycin resistance by use of a rapid sloppy molecular beacon-based assay identifies more cases of low-level drug resistance than phenotypic Lowenstein-Jensen testing // J. Clin. Microbiol. – 2015. – Vol. 53. – N. 1. – P.43-51.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng S., Cui Z., Li Y., Hu Z. Diagnostic accuracy of a molecular drug susceptibility testing method for the antituberculosis drug ethambutol: a systematic review and meta-analysis // J. Clin. Microbiol. – 2014. – Vol. 52. – P. 2913-2924.</mixed-citation><mixed-citation xml:lang="en">Cheng S., Cui Z., Li Y., Hu Z. Diagnostic accuracy of a molecular drug susceptibility testing method for the antituberculosis drug ethambutol: a systematic review and meta-analysis // J. Clin. Microbiol. – 2014. – Vol. 52. – P. 2913-2924.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Chiang S., Brooks M., Jenkins H., Rubenstein D., Seddon J., van de Water B. et al. Concordance of drug resistance profiles between persons with drug-resistant tuberculosis and their household contacts: a systematic review and meta-analysis // Clin. Infect. Dis. – 2020. – May 25: ciaa613. doi: 10.1093/cid/ciaa613.</mixed-citation><mixed-citation xml:lang="en">Chiang S., Brooks M., Jenkins H., Rubenstein D., Seddon J., van de Water B. et al. Concordance of drug resistance profiles between persons with drug-resistant tuberculosis and their household contacts: a systematic review and meta-analysis // Clin. Infect. Dis. – 2020. – May 25: ciaa613. doi: 10.1093/cid/ciaa613.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Chisompola NK, Streicher EM, Muchemwa CMK, Warren RM, Sampson SL. Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review // BMC Infect. Dis. – 2020. – Vol. 20. – N. 1:344. doi: 10.1186/s12879-020-05031-5.</mixed-citation><mixed-citation xml:lang="en">Chisompola NK, Streicher EM, Muchemwa CMK, Warren RM, Sampson SL. Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review // BMC Infect. Dis. – 2020. – Vol. 20. – N. 1:344. doi: 10.1186/s12879-020-05031-5.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cho S., Lee H., Franzblau S. Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA) for Mycobacterium tuberculosis // Methods. Mol. Biol. – 2015. – 1285. – P. 281-292. doi: 10.1007/978-1-4939-2450-9_17.</mixed-citation><mixed-citation xml:lang="en">Cho S., Lee H., Franzblau S. Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA) for Mycobacterium tuberculosis // Methods. Mol. Biol. – 2015. – 1285. – P. 281-292. doi: 10.1007/978-1-4939-2450-9_17.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">CLSI. Clinical and Laboratory Standards Institute. Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes; approved standard – second edition: document M24-A2. – CLSI, Wayne, PA, USA, 2011.</mixed-citation><mixed-citation xml:lang="en">CLSI. Clinical and Laboratory Standards Institute. Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes; approved standard – second edition: document M24-A2. – CLSI, Wayne, PA, USA, 2011.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">CLSI. Susceptibility testing of mycobacteria, Nocardia spp., and other aerobic actinomycetes, 3rd ed, CLSI standard document M24. Clinical and Laboratory Standards Institute, 2018. – Wayne, PA., 2018.</mixed-citation><mixed-citation xml:lang="en">CLSI. Susceptibility testing of mycobacteria, Nocardia spp., and other aerobic actinomycetes, 3rd ed, CLSI standard document M24. Clinical and Laboratory Standards Institute, 2018. – Wayne, PA., 2018.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Coban A., Deveci A., Sunter A., Palomino J., Martin A. Resazurin microtiter assay for isoniazid, rifampicin, ethambutol and streptomycin resistance detection in Mycobacterium tuberculosis: Updated meta-analysis // Int. J. Mycobacteriol. – 2014. – Vol. 3. – N. 4. – P. 230-241. doi: 10.1016/j.ijmyco.2014.09.002.</mixed-citation><mixed-citation xml:lang="en">Coban A., Deveci A., Sunter A., Palomino J., Martin A. Resazurin microtiter assay for isoniazid, rifampicin, ethambutol and streptomycin resistance detection in Mycobacterium tuberculosis: Updated meta-analysis // Int. J. Mycobacteriol. – 2014. – Vol. 3. – N. 4. – P. 230-241. doi: 10.1016/j.ijmyco.2014.09.002.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Coban A., Akbal A., Uzun M., Durupinar B. et al. Evaluation of four colourimetric susceptibility tests for the rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates //Mem. Inst. Oswaldo. Cruz. – 2015. – Vol. 110. – N. 5. – P. 649-654. doi: 10.1590/0074-02760150136.</mixed-citation><mixed-citation xml:lang="en">Coban A., Akbal A., Uzun M., Durupinar B. et al. Evaluation of four colourimetric susceptibility tests for the rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates //Mem. Inst. Oswaldo. Cruz. – 2015. – Vol. 110. – N. 5. – P. 649-654. doi: 10.1590/0074-02760150136.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">D’Ambrosio L., Centis R., Tiberi S., Tadolini M., Dalcolmo M., Rendon A. et al. Delamanid and bedaquiline to treat multidrug-resistant and extensively drug-resistant tuberculosis in children: a systematic review // J. Thorac. Dis. – 2017. – Vol. 9. – N. 7. – P. 2093-2101. doi: 10.21037/jtd.2017.06.16.</mixed-citation><mixed-citation xml:lang="en">D’Ambrosio L., Centis R., Tiberi S., Tadolini M., Dalcolmo M., Rendon A. et al. Delamanid and bedaquiline to treat multidrug-resistant and extensively drug-resistant tuberculosis in children: a systematic review // J. Thorac. Dis. – 2017. – Vol. 9. – N. 7. – P. 2093-2101. doi: 10.21037/jtd.2017.06.16.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Danilchanka O., Pavlenok M., Niederweis M. Role of porins for uptake of antibiotics by Mycobacterium smegmatis // Antimicrob. Agents. Chemother. – 2008. – Vol. 52. – N. 9. – P. 3127-3134.</mixed-citation><mixed-citation xml:lang="en">Danilchanka O., Pavlenok M., Niederweis M. Role of porins for uptake of antibiotics by Mycobacterium smegmatis // Antimicrob. Agents. Chemother. – 2008. – Vol. 52. – N. 9. – P. 3127-3134.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Deshpande D., Alffenaar J., Köser C., Dheda K. et al. The detection of medication sensitivity of M. tuberculosis isolated from patients with tuberculosis with multiple medication resistance in test-system «Sensititre MycoTB» // Clin. Infect. Dis. – 2018. – Vol. 28. – Suppl. 3. – S308-S316. doi: 10.1093/cid/ciy624.</mixed-citation><mixed-citation xml:lang="en">Deshpande D., Alffenaar J., Köser C., Dheda K. et al. The detection of medication sensitivity of M. tuberculosis isolated from patients with tuberculosis with multiple medication resistance in test-system «Sensititre MycoTB» // Clin. Infect. Dis. – 2018. – Vol. 28. – Suppl. 3. – S308-S316. doi: 10.1093/cid/ciy624.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Dheda K., Gumbo T., Gandhi N. et al. Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis // Lancet. Respir. Med. – 2014. – Vol. 2. – N. 4. – P. 321-338.</mixed-citation><mixed-citation xml:lang="en">Dheda K., Gumbo T., Gandhi N. et al. Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis // Lancet. Respir. Med. – 2014. – Vol. 2. – N. 4. – P. 321-338.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Dheda K., Gumbo T., Maartens G. et al. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis // Lancet. Respir. Med. – 2017. – S2213-2600(17) 30079-6. doi:10.1016/S2213-2600(17)30079-6.</mixed-citation><mixed-citation xml:lang="en">Dheda K., Gumbo T., Maartens G. et al. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis // Lancet. Respir. Med. – 2017. – S2213-2600(17) 30079-6. doi:10.1016/S2213-2600(17)30079-6.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Dixit P., Singh U., Sharma P., Jain A., Dixit P. et al. Evaluation of nitrate reduction assay, resazurin microtiter assay and microscopic observation drug susceptibility assay for first line antitubercular drug susceptibility testing of clinical isolates of M. tuberculosis // J. Microbiol. Methods. – 2012. – Vol. 88. – N. 1. – P. 122-126. doi: 10.1016/j.mimet.2011.11.006.</mixed-citation><mixed-citation xml:lang="en">Dixit P., Singh U., Sharma P., Jain A., Dixit P. et al. Evaluation of nitrate reduction assay, resazurin microtiter assay and microscopic observation drug susceptibility assay for first line antitubercular drug susceptibility testing of clinical isolates of M. tuberculosis // J. Microbiol. Methods. – 2012. – Vol. 88. – N. 1. – P. 122-126. doi: 10.1016/j.mimet.2011.11.006.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Dodd P., Sismanidis C., Seddon J. et al. Global burden of drug-resistant tuberculosis in children: a mathematical modelling study // Lancet. Infect. Dis. – 2016. – Vol. 16. – N. 10. – P. 1193-1201.</mixed-citation><mixed-citation xml:lang="en">Dodd P., Sismanidis C., Seddon J. et al. Global burden of drug-resistant tuberculosis in children: a mathematical modelling study // Lancet. Infect. Dis. – 2016. – Vol. 16. – N. 10. – P. 1193-1201.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Engström A, Antonenka U, Kadyrov A, et al. Population structure of drug-resistant Mycobacterium tuberculosis in Central Asia // BMC Infect. Dis. – 2019. – Vol. 19. – N. 1:908. Published 2019 Oct 29. doi:10.1186/s12879-019-4480-7.</mixed-citation><mixed-citation xml:lang="en">Engström A, Antonenka U, Kadyrov A, et al. Population structure of drug-resistant Mycobacterium tuberculosis in Central Asia // BMC Infect. Dis. – 2019. – Vol. 19. – N. 1:908. Published 2019 Oct 29. doi:10.1186/s12879-019-4480-7.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">FDA. Anti-Infective Drugs Advisory Committec Meeting. Silver Spring, MD, Nov. 28, 2012, Sirturo™ (bedaquilin).</mixed-citation><mixed-citation xml:lang="en">FDA. Anti-Infective Drugs Advisory Committec Meeting. Silver Spring, MD, Nov. 28, 2012, Sirturo™ (bedaquilin).</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Fenner L., Egger M., Bodmer T., Altpeter E., Zwahlen M., Jaton K. et al. Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2012. – Vol. 56. – P. 3047-3053.</mixed-citation><mixed-citation xml:lang="en">Fenner L., Egger M., Bodmer T., Altpeter E., Zwahlen M., Jaton K. et al. Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2012. – Vol. 56. – P. 3047-3053.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Ferber D. Biochemistry. Protein that mimics DNA helps tuberculosis bacteria resist antibiotics // Science. – 2005. – Vol. 308. – N. 5727. – 1480 p.</mixed-citation><mixed-citation xml:lang="en">Ferber D. Biochemistry. Protein that mimics DNA helps tuberculosis bacteria resist antibiotics // Science. – 2005. – Vol. 308. – N. 5727. – 1480 p.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Flores A., Parsons L., Pavelka M. Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics // Microbiology. – 2005. – Vol. 151. – P. 521-532.</mixed-citation><mixed-citation xml:lang="en">Flores A., Parsons L., Pavelka M. Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics // Microbiology. – 2005. – Vol. 151. – P. 521-532.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Georghiou S., Magana M., Garfein R., Catanzaro D., Catanzaro A., Rodwell T. Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review // PLoS One. – 2012. – Vol. 7. – N. 3. – e33275.</mixed-citation><mixed-citation xml:lang="en">Georghiou S., Magana M., Garfein R., Catanzaro D., Catanzaro A., Rodwell T. Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review // PLoS One. – 2012. – Vol. 7. – N. 3. – e33275.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Ginsburg A., Grosset J., Bishai W. Fluoroquinolones, tuberculosis, and resistance // Lancet Infect. Dis. – 2003. – Vol. 3. – P. 432-442.</mixed-citation><mixed-citation xml:lang="en">Ginsburg A., Grosset J., Bishai W. Fluoroquinolones, tuberculosis, and resistance // Lancet Infect. Dis. – 2003. – Vol. 3. – P. 432-442.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Goossens S., Sampson S., Van Rie A. Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis // Clin. Microbiol. Rev. – 2020. – Vol. 34. – N. 1:e00141-20. doi: 10.1128/CMR.00141-20.</mixed-citation><mixed-citation xml:lang="en">Goossens S., Sampson S., Van Rie A. Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis // Clin. Microbiol. Rev. – 2020. – Vol. 34. – N. 1:e00141-20. doi: 10.1128/CMR.00141-20.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Grace Lin S-Y., Desmond E., Bonato D., Gross W., Siddiqi S. Multicenter Evaluation of Bactec MGIT 960 System for Second-Line Drug Susceptibility Testing of Mycobacterium Tuberculosis Complex // J. Clin. Microbiol. – 2009. – Vol. 47. – N. 11. – P. 3630-3634. doi: 10.1128/JCM.00803-09.</mixed-citation><mixed-citation xml:lang="en">Grace Lin S-Y., Desmond E., Bonato D., Gross W., Siddiqi S. Multicenter Evaluation of Bactec MGIT 960 System for Second-Line Drug Susceptibility Testing of Mycobacterium Tuberculosis Complex // J. Clin. Microbiol. – 2009. – Vol. 47. – N. 11. – P. 3630-3634. doi: 10.1128/JCM.00803-09.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Hameed H., Islam M., Chhotaray C. et al. Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains // Front. Cell. Infect. Microbiol. – 2018. – Vol. 8:114. Published 2018 Apr 10. doi:10.3389/fcimb.2018.00114.</mixed-citation><mixed-citation xml:lang="en">Hameed H., Islam M., Chhotaray C. et al. Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains // Front. Cell. Infect. Microbiol. – 2018. – Vol. 8:114. Published 2018 Apr 10. doi:10.3389/fcimb.2018.00114.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Hargreaves S., Lönnroth K., Nellums L. et al. Response to Letter to the Editor by M. van der Werf, V. Hollo and C. Ködmön concerning ‘Multidrug-resistant tuberculosis and migration to Europe’ // Clin. Microbiol. Infect. – 2017. – Vol. 23. – N. 8. – P. 580. doi: 10.1016/j.cmi.2017.02.022.</mixed-citation><mixed-citation xml:lang="en">Hargreaves S., Lönnroth K., Nellums L. et al. Response to Letter to the Editor by M. van der Werf, V. Hollo and C. Ködmön concerning ‘Multidrug-resistant tuberculosis and migration to Europe’ // Clin. Microbiol. Infect. – 2017. – Vol. 23. – N. 8. – P. 580. doi: 10.1016/j.cmi.2017.02.022.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Hashemian S., Farhadi T., Ganjparvar M. Linezolid: a review of its properties, function, and use in critical care // Drug Des. Devel. Ther. – 2018. – Vol. 12. – P. 1759-1767. Published 2018 Jun 18. doi:10.2147/DDDT.S164515.</mixed-citation><mixed-citation xml:lang="en">Hashemian S., Farhadi T., Ganjparvar M. Linezolid: a review of its properties, function, and use in critical care // Drug Des. Devel. Ther. – 2018. – Vol. 12. – P. 1759-1767. Published 2018 Jun 18. doi:10.2147/DDDT.S164515.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Hashmi H., Javed H., Jamil N. Emerging epidemic of drug resistant tuberculosis in vulnerable populations of developing countries // Afr. Health. Sci. – 2017. – Vol. 17. – N. 2. – P. 599-602.</mixed-citation><mixed-citation xml:lang="en">Hashmi H., Javed H., Jamil N. Emerging epidemic of drug resistant tuberculosis in vulnerable populations of developing countries // Afr. Health. Sci. – 2017. – Vol. 17. – N. 2. – P. 599-602.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Heifets L. Drug susceptibility in the chemotherapy of mycobacterial infections. – CRC Press. Boca Raton Ann Arbor Boston. London. – 2000. – 212 p.</mixed-citation><mixed-citation xml:lang="en">Heifets L. Drug susceptibility in the chemotherapy of mycobacterial infections. – CRC Press. Boca Raton Ann Arbor Boston. London. – 2000. – 212 p.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Huitric E., Verhasselt P., Koul A., Andries K., Hoffner S. et al. Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor // Antimicrob. Agents. Chemother. – 2010. – Vol. 54. – P. 1022-1028.</mixed-citation><mixed-citation xml:lang="en">Huitric E., Verhasselt P., Koul A., Andries K., Hoffner S. et al. Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor // Antimicrob. Agents. Chemother. – 2010. – Vol. 54. – P. 1022-1028.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Huynh J., Marais B. Multidrug-resistant tuberculosis infection and disease in children: a review of new and repurposed drugs // Ther. Adv. Infect. Dis. – 2019. – Vol. 6:2049936119864737. doi:10.1177/2049936119864737.</mixed-citation><mixed-citation xml:lang="en">Huynh J., Marais B. Multidrug-resistant tuberculosis infection and disease in children: a review of new and repurposed drugs // Ther. Adv. Infect. Dis. – 2019. – Vol. 6:2049936119864737. doi:10.1177/2049936119864737.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Ismail N., Omar S., Ismail N., Peters R. Collated data of mutation frequencies and associated genetic variants of bedaquiline, clofazimine and linezolid resistance in Mycobacterium tuberculosis // Data Brief. 2018. – Vol. 20. – P. 1975-1983. Published 2018 Sep 24. doi:10.1016/j.dib.2018.09.057.</mixed-citation><mixed-citation xml:lang="en">Ismail N., Omar S., Ismail N., Peters R. Collated data of mutation frequencies and associated genetic variants of bedaquiline, clofazimine and linezolid resistance in Mycobacterium tuberculosis // Data Brief. 2018. – Vol. 20. – P. 1975-1983. Published 2018 Sep 24. doi:10.1016/j.dib.2018.09.057.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Jaglal P., Pillay M., Mlisana K. Resazurin microtitre plate assay and Sensititre® MycoTB for detection of Mycobacterium tuberculosis resistance in a high tuberculosis resistance setting // Afr. J. Lab. Med. – 2019. – Vol. 8. – N. 1: 840. doi: 10.4102/ajlm.v8i1.840.</mixed-citation><mixed-citation xml:lang="en">Jaglal P., Pillay M., Mlisana K. Resazurin microtitre plate assay and Sensititre® MycoTB for detection of Mycobacterium tuberculosis resistance in a high tuberculosis resistance setting // Afr. J. Lab. Med. – 2019. – Vol. 8. – N. 1: 840. doi: 10.4102/ajlm.v8i1.840.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Jang J., Jung Y., Choi J., Jung H., Ryoo S. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis // J. Microbiol. – 2017. – Vol. 55. – N. 6. – P. 483-487. doi: 10.1007/s12275-017-6630-1.</mixed-citation><mixed-citation xml:lang="en">Jang J., Jung Y., Choi J., Jung H., Ryoo S. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis // J. Microbiol. – 2017. – Vol. 55. – N. 6. – P. 483-487. doi: 10.1007/s12275-017-6630-1.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Jarlier V., Nikaido H. Mycobacterial cell wall: structure and role in natural resistance to antibiotics // FEMS Microbiol. Lett. – 1994. – Vol. 123. – P. 11-18.</mixed-citation><mixed-citation xml:lang="en">Jarlier V., Nikaido H. Mycobacterial cell wall: structure and role in natural resistance to antibiotics // FEMS Microbiol. Lett. – 1994. – Vol. 123. – P. 11-18.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Kadura S., King N., Nakhoul M. et al. Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid // J. Antimicrob. Chemother. – 2020. – dkaa136. doi:10.1093/jac/dkaa136.</mixed-citation><mixed-citation xml:lang="en">Kadura S., King N., Nakhoul M. et al. Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid // J. Antimicrob. Chemother. – 2020. – dkaa136. doi:10.1093/jac/dkaa136.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Kaniga K., Cirillo D., Hoffner S., Ismail N., Kaur D., Lounis N. et al. A multilaboratory, multicountry study to determine mic quality control ranges for phenotypic drug susceptibility testing of selected first-line antituberculosis drugs, second-line injectables, fluoroquinolones, clofazimine, and linezolid // J. Clin. Microbiol. – 2016. – Vol. 54. – N. 12. – P. 2963-2968.</mixed-citation><mixed-citation xml:lang="en">Kaniga K., Cirillo D., Hoffner S., Ismail N., Kaur D., Lounis N. et al. A multilaboratory, multicountry study to determine mic quality control ranges for phenotypic drug susceptibility testing of selected first-line antituberculosis drugs, second-line injectables, fluoroquinolones, clofazimine, and linezolid // J. Clin. Microbiol. – 2016. – Vol. 54. – N. 12. – P. 2963-2968.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Karekar S., Marathe P. Current Status of Delamanid in the Management of MDR Tuberculosis // J. Assoc. Physicians. India. – 2018. – Vol. 66. – N. 7. – P. 72‐75.</mixed-citation><mixed-citation xml:lang="en">Karekar S., Marathe P. Current Status of Delamanid in the Management of MDR Tuberculosis // J. Assoc. Physicians. India. – 2018. – Vol. 66. – N. 7. – P. 72‐75.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Keller P., Hömke R., Ritter C., Valsesia G., Bloemberg G., Böttger E. Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST // Antimicrob. Agents. Chemother. – 2015. – Vol. 59. – N. 7. – P. 4352-4355. doi: 10.1128/AAC.00614-15.</mixed-citation><mixed-citation xml:lang="en">Keller P., Hömke R., Ritter C., Valsesia G., Bloemberg G., Böttger E. Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST // Antimicrob. Agents. Chemother. – 2015. – Vol. 59. – N. 7. – P. 4352-4355. doi: 10.1128/AAC.00614-15.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Khawbung J., Nath D., Chakraborty S. Drug resistant tuberculosis: a review // Comp. Immunol. Microbiol. Infect. Dis. – 2021. – Vol. 74:101574. doi: 10.1016/ j.cimid.2020.101574.</mixed-citation><mixed-citation xml:lang="en">Khawbung J., Nath D., Chakraborty S. Drug resistant tuberculosis: a review // Comp. Immunol. Microbiol. Infect. Dis. – 2021. – Vol. 74:101574. doi: 10.1016/ j.cimid.2020.101574.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Kodama C., Lange B., Olaru I. et al. Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB: a systematic review and meta-analysis // Eur. Respir. J. – 2017. – Vol. 26. – P. 50-54.</mixed-citation><mixed-citation xml:lang="en">Kodama C., Lange B., Olaru I. et al. Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB: a systematic review and meta-analysis // Eur. Respir. J. – 2017. – Vol. 26. – P. 50-54.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Li G., Zhang J., Guo Q., Jiang Y., Wei J., Zhao L-L. et al. Efflux pump gene expression in multidrug-resistant Mycobacterium tuberculosis clinical isolates // PLoS One. – 2015. – Vol. 10. – N. 2. – e0119013.</mixed-citation><mixed-citation xml:lang="en">Li G., Zhang J., Guo Q., Jiang Y., Wei J., Zhao L-L. et al. Efflux pump gene expression in multidrug-resistant Mycobacterium tuberculosis clinical isolates // PLoS One. – 2015. – Vol. 10. – N. 2. – e0119013.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Li J., Gao X., Luo T., Wu J., Sun G., Liu Q. et al. Association of gyrA/B mutations and resistance levels to fluoroquinolones in clinical isolates of Mycobacterium tuberculosis. Emerging microbes and infections // Emerg. Microbes. Infect. – 2014. – Vol. 3. – N. 3. – e19.</mixed-citation><mixed-citation xml:lang="en">Li J., Gao X., Luo T., Wu J., Sun G., Liu Q. et al. Association of gyrA/B mutations and resistance levels to fluoroquinolones in clinical isolates of Mycobacterium tuberculosis. Emerging microbes and infections // Emerg. Microbes. Infect. – 2014. – Vol. 3. – N. 3. – e19.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Li X-Z., Nikaido H. Efflux-mediated drug resistance in bacteria // Drugs. – 2004. – Vol. 64. – N. 2. – P. 159-204.</mixed-citation><mixed-citation xml:lang="en">Li X-Z., Nikaido H. Efflux-mediated drug resistance in bacteria // Drugs. – 2004. – Vol. 64. – N. 2. – P. 159-204.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y., Matsumoto M., Ishida H., Ohguro K., Yoshitake M., Gupta R. et al. Delamanid: From discovery to its use for pulmonary multidrug-resistant tuberculosis (MDR-TB) // Tuberculosis (Edinb). – 2018. – Vol. 111. – P. 20-30. doi: 10.1016/j.tube.2018.04.008.</mixed-citation><mixed-citation xml:lang="en">Liu Y., Matsumoto M., Ishida H., Ohguro K., Yoshitake M., Gupta R. et al. Delamanid: From discovery to its use for pulmonary multidrug-resistant tuberculosis (MDR-TB) // Tuberculosis (Edinb). – 2018. – Vol. 111. – P. 20-30. doi: 10.1016/j.tube.2018.04.008.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez B., de Oliveira R., Pinhata J., Chimara E., Ascencio E. et al. Bedaquiline and Linezolid MIC Distributions and Epidemiological Cut-Off Values for Mycobacterium Tuberculosis in the Latin American Region // J. Antimicrob. Chemother. – 2019. – Vol. 74. – N. 2. – P. 373-379. doi: 10.1093/jac/dky414.</mixed-citation><mixed-citation xml:lang="en">Lopez B., de Oliveira R., Pinhata J., Chimara E., Ascencio E. et al. Bedaquiline and Linezolid MIC Distributions and Epidemiological Cut-Off Values for Mycobacterium Tuberculosis in the Latin American Region // J. Antimicrob. Chemother. – 2019. – Vol. 74. – N. 2. – P. 373-379. doi: 10.1093/jac/dky414.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Machado D., Perdigão J., Ramos J., Couto I., Portugal I., Ritter C. et al. High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations // J. Antimicrob. Chemother. – 2013. – Vol. 68. – P. 1728-1732.</mixed-citation><mixed-citation xml:lang="en">Machado D., Perdigão J., Ramos J., Couto I., Portugal I., Ritter C. et al. High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations // J. Antimicrob. Chemother. – 2013. – Vol. 68. – P. 1728-1732.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Martin A., Morcillo N., Lemus D., Montoro E., Telles M., Simboli N. at. et. Multicenter study of MTT and resazurin assays for testing susceptibility to first-line anti-tuberculosis drugs // Int. J. Tuberc. Lung. Dis. – 2005. – Vol. 9. – N. 8. – P. 901-906.</mixed-citation><mixed-citation xml:lang="en">Martin A., Morcillo N., Lemus D., Montoro E., Telles M., Simboli N. at. et. Multicenter study of MTT and resazurin assays for testing susceptibility to first-line anti-tuberculosis drugs // Int. J. Tuberc. Lung. Dis. – 2005. – Vol. 9. – N. 8. – P. 901-906.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Martin I., Dionne K., Deml S., Wengenack N. et al. Automated broth-based systems versus the MYCOTB plate for antimicrobial susceptibility testing of the Mycobacterium tuberculosis complex: challenges in interpretation // Diagn. Microbiol. Infect. Dis. – 2018. – Vol. 91. – N. 1. – P. 38-41. doi: 10.1016/j.diagmicrobio.2018.01.002.</mixed-citation><mixed-citation xml:lang="en">Martin I., Dionne K., Deml S., Wengenack N. et al. Automated broth-based systems versus the MYCOTB plate for antimicrobial susceptibility testing of the Mycobacterium tuberculosis complex: challenges in interpretation // Diagn. Microbiol. Infect. Dis. – 2018. – Vol. 91. – N. 1. – P. 38-41. doi: 10.1016/j.diagmicrobio.2018.01.002.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Martin L., Coronel J., Faulx D., Valdez M., Metzler M., Crudder C. et al. A field evaluation of the Hardy TB MODS Kit™ for the rapid phenotypic diagnosis of tuberculosis and multi-drug resistant tuberculosis // PLoS One. – 2014. – Vol. 9. – N. 9: e107258. doi: 10.1371/j.</mixed-citation><mixed-citation xml:lang="en">Martin L., Coronel J., Faulx D., Valdez M., Metzler M., Crudder C. et al. A field evaluation of the Hardy TB MODS Kit™ for the rapid phenotypic diagnosis of tuberculosis and multi-drug resistant tuberculosis // PLoS One. – 2014. – Vol. 9. – N. 9: e107258. doi: 10.1371/j.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Mathys V., Wintjens R., Lefevre P. et al. Molecular genetics of paraaminosalicylic acid resistance in clinical isolates and spontaneousmutants of Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2009. – Vol. 53. – P. 2100-9.</mixed-citation><mixed-citation xml:lang="en">Mathys V., Wintjens R., Lefevre P. et al. Molecular genetics of paraaminosalicylic acid resistance in clinical isolates and spontaneousmutants of Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2009. – Vol. 53. – P. 2100-9.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Maus C., Plikaytis B., Shinnick T. Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2005. – Vol. 49. – N. 8. – P. 3192-3197.</mixed-citation><mixed-citation xml:lang="en">Maus C., Plikaytis B., Shinnick T. Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2005. – Vol. 49. – N. 8. – P. 3192-3197.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">McCallum A., Sloan D. The importance of clinical pharmacokinetic–pharmacodynamic studies in unraveling the determinants of early and late tuberculosis outcomes // Int. J. Pharmacokinet. – 2017. – Vol. 2. – N. 3. – P. 195-212.</mixed-citation><mixed-citation xml:lang="en">McCallum A., Sloan D. The importance of clinical pharmacokinetic–pharmacodynamic studies in unraveling the determinants of early and late tuberculosis outcomes // Int. J. Pharmacokinet. – 2017. – Vol. 2. – N. 3. – P. 195-212.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Mesfin Y., Hailemariam D., Biadglign S. et al. Association between HIV/AIDS and multi-drug resistance tuberculosis: a systematic review and meta-analysis // PLoS One. – 2014. – Vol. 9. – e82235.</mixed-citation><mixed-citation xml:lang="en">Mesfin Y., Hailemariam D., Biadglign S. et al. Association between HIV/AIDS and multi-drug resistance tuberculosis: a systematic review and meta-analysis // PLoS One. – 2014. – Vol. 9. – e82235.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Miotto P., Zhang Y., Cirillo D., Yam W. Drug resistance mechanisms and drug susceptibility testing for tuberculosis. Invited Review Series: Tubercolosis updates 2018 // Respirology. – 2018. – Vol. 23. – N. 12. – P. 1098-1113.</mixed-citation><mixed-citation xml:lang="en">Miotto P., Zhang Y., Cirillo D., Yam W. Drug resistance mechanisms and drug susceptibility testing for tuberculosis. Invited Review Series: Tubercolosis updates 2018 // Respirology. – 2018. – Vol. 23. – N. 12. – P. 1098-1113.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Munir A., Vedithi S., Chaplin A., Blundell T. Genomics, computational biology and drug discovery for mycobacterial infections: fighting the emergence of resistance // Front. Genet. – 2020. – Vol. 11. – P. 965. doi: 10.3389/fgene.2020.00965.</mixed-citation><mixed-citation xml:lang="en">Munir A., Vedithi S., Chaplin A., Blundell T. Genomics, computational biology and drug discovery for mycobacterial infections: fighting the emergence of resistance // Front. Genet. – 2020. – Vol. 11. – P. 965. doi: 10.3389/fgene.2020.00965.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Muthukrishnan L. Multidrug resistant tuberculosis - Diagnostic challenges and its conquering by nanotechnology approach – an overview // Chem. Biol. Interact. – 2021. – Vol. 26. – N. 337:109397. doi: 10.1016/j.cbi.2021.109397.</mixed-citation><mixed-citation xml:lang="en">Muthukrishnan L. Multidrug resistant tuberculosis - Diagnostic challenges and its conquering by nanotechnology approach – an overview // Chem. Biol. Interact. – 2021. – Vol. 26. – N. 337:109397. doi: 10.1016/j.cbi.2021.109397.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Nasiri M., Haeili M., Ghazi M., Goudarzi H., Pormohammad A., Fooladi A., Feizabadi M. New insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria // Front Microbiol. – 2017. – Vol. 8. – P. 681.</mixed-citation><mixed-citation xml:lang="en">Nasiri M., Haeili M., Ghazi M., Goudarzi H., Pormohammad A., Fooladi A., Feizabadi M. New insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria // Front Microbiol. – 2017. – Vol. 8. – P. 681.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen T., Anthony R., Cao T., Bañuls A., Nguyen V., Vu D. et al. Delamanid Resistance: Update and Clinical Management // Clin. Infect. Dis. – 2020. – Vol. 71. – N. 12. – P. 3252-3259. doi: 10.1093/cid/ciaa755.</mixed-citation><mixed-citation xml:lang="en">Nguyen T., Anthony R., Cao T., Bañuls A., Nguyen V., Vu D. et al. Delamanid Resistance: Update and Clinical Management // Clin. Infect. Dis. – 2020. – Vol. 71. – N. 12. – P. 3252-3259. doi: 10.1093/cid/ciaa755.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Nieto Ramirez L., Quintero Vargas K., Diaz G. Whole genome sequencing for the analysis of drug resistant strains of Mycobacterium tuberculosis: a systematic review for bedaquiline and delamanid // Antibiotics (Basel). – 2020. – Vol. 9. – N. 3. – P. 133. doi: 10.3390/antibiotics9030133.</mixed-citation><mixed-citation xml:lang="en">Nieto Ramirez L., Quintero Vargas K., Diaz G. Whole genome sequencing for the analysis of drug resistant strains of Mycobacterium tuberculosis: a systematic review for bedaquiline and delamanid // Antibiotics (Basel). – 2020. – Vol. 9. – N. 3. – P. 133. doi: 10.3390/antibiotics9030133.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Nosova E., Bukatina A., Isaeva Y., Makarova M., Galkina K., Moroz A. Analysis of mutations in the gyrA and gyrB genes and their association with the resistance of Mycobacterium tuberculosis to levofloxacin, moxifloxacin and gatifloxacin // J. Med. Microbiol. – 2013. – Vol. 62. – P. 108-113.</mixed-citation><mixed-citation xml:lang="en">Nosova E., Bukatina A., Isaeva Y., Makarova M., Galkina K., Moroz A. Analysis of mutations in the gyrA and gyrB genes and their association with the resistance of Mycobacterium tuberculosis to levofloxacin, moxifloxacin and gatifloxacin // J. Med. Microbiol. – 2013. – Vol. 62. – P. 108-113.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Palomino J., Martin A. Drug resistance mechanisms in Mycobacterium tuberculosis // Antibiotics (Basel). – 2014. – Vol. 3. – P. 317-340.</mixed-citation><mixed-citation xml:lang="en">Palomino J., Martin A. Drug resistance mechanisms in Mycobacterium tuberculosis // Antibiotics (Basel). – 2014. – Vol. 3. – P. 317-340.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Pang Y., Zong Z., Huo F. et al. In vitro drug susceptibility of bedaquiline, delamanid, linezolid, clofazimine, moxifloxacin, and gatifloxacin against extensively drug-resistant tuberculosis in Beijing, China // Antimicrob. Agents. Chemother. – 2017. – Vol. 61. – N. 10. – pii: e00900-17.</mixed-citation><mixed-citation xml:lang="en">Pang Y., Zong Z., Huo F. et al. In vitro drug susceptibility of bedaquiline, delamanid, linezolid, clofazimine, moxifloxacin, and gatifloxacin against extensively drug-resistant tuberculosis in Beijing, China // Antimicrob. Agents. Chemother. – 2017. – Vol. 61. – N. 10. – pii: e00900-17.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Peretokina I., Krylova L., Antonova O., Kholina M., Kulagina E., Nosova E. et al. Reduced susceptibility and resistance to bedaquiline in clinical M. tuberculosis isolates // J. Infect. – 2020. – Vol. 80. – N. 5. – P. 527-535. doi: 10.1016/j.jinf. 2020.01.007.</mixed-citation><mixed-citation xml:lang="en">Peretokina I., Krylova L., Antonova O., Kholina M., Kulagina E., Nosova E. et al. Reduced susceptibility and resistance to bedaquiline in clinical M. tuberculosis isolates // J. Infect. – 2020. – Vol. 80. – N. 5. – P. 527-535. doi: 10.1016/j.jinf. 2020.01.007.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Ramaswamy S., Amin A., Göksel S., Stager C., Dou S., El Sahly H. et al. Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis // Antimicrob. Agents Chemother. – 2000. – Vol. 44. – P. 326-336.</mixed-citation><mixed-citation xml:lang="en">Ramaswamy S., Amin A., Göksel S., Stager C., Dou S., El Sahly H. et al. Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis // Antimicrob. Agents Chemother. – 2000. – Vol. 44. – P. 326-336.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Richter E., Rüsch-Gerdes S., Hillemann D. First Linezolid-Resistant Clinical Isolates of Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2007. – Vol. 51. – N. 4. – P. 1534-1536. doi: 10.1128/AAC.01113-06.</mixed-citation><mixed-citation xml:lang="en">Richter E., Rüsch-Gerdes S., Hillemann D. First Linezolid-Resistant Clinical Isolates of Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2007. – Vol. 51. – N. 4. – P. 1534-1536. doi: 10.1128/AAC.01113-06.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Rumende C. Risk Factors for Multidrug-resistant Tuberculosis // Acta. Med. Indones. – 2018. – Vol. 50. – N. 1. – P. 1-2.</mixed-citation><mixed-citation xml:lang="en">Rumende C. Risk Factors for Multidrug-resistant Tuberculosis // Acta. Med. Indones. – 2018. – Vol. 50. – N. 1. – P. 1-2.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Rüsch-Gerdes S., Pfyffer G., Casal M., Chadwick М., Siddiqi S. Multicenter laboratory validation of the BACTEC MGIT 960 technique for testing susceptibilities of Mycobacterium tuberculosis to classical second-line drugs and newer antimicrobials // J. Clin. Microbiol. – 2006. – Vol. 44. – N. 3. – P. 688-692. doi: 10.1128/JCM.44.3.688-692.2006.</mixed-citation><mixed-citation xml:lang="en">Rüsch-Gerdes S., Pfyffer G., Casal M., Chadwick М., Siddiqi S. Multicenter laboratory validation of the BACTEC MGIT 960 technique for testing susceptibilities of Mycobacterium tuberculosis to classical second-line drugs and newer antimicrobials // J. Clin. Microbiol. – 2006. – Vol. 44. – N. 3. – P. 688-692. doi: 10.1128/JCM.44.3.688-692.2006.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Saxena S., Spaink H., Forn-Cuní G. Drug Resistance in Nontuberculous Mycobacteria: Mechanisms and Models // Biology (Basel). – 2021. – Vol. 10. – N. 2. – P. 96. doi: 10.3390/biology10020096.</mixed-citation><mixed-citation xml:lang="en">Saxena S., Spaink H., Forn-Cuní G. Drug Resistance in Nontuberculous Mycobacteria: Mechanisms and Models // Biology (Basel). – 2021. – Vol. 10. – N. 2. – P. 96. doi: 10.3390/biology10020096.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Schön T., Miotto P., Köser C., Viveiros M., Boettger E., Cambau E. Mycobacterium tuberculosis drug resistance testing: challenges, recent developments and perspectives // Clin. Microbiol. Infect. – 2017. – Vol. 23. – N. 3. – P. 154-160.</mixed-citation><mixed-citation xml:lang="en">Schön T., Miotto P., Köser C., Viveiros M., Boettger E., Cambau E. Mycobacterium tuberculosis drug resistance testing: challenges, recent developments and perspectives // Clin. Microbiol. Infect. – 2017. – Vol. 23. – N. 3. – P. 154-160.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma P., Lalwani J., Pandey P., Thakur A. Factors Associated with the Development of Secondary Multidrug-resistant Tuberculosis // Int. J. Prev. Med. –2019. – Vol. 10. – P. 67. doi: 10.4103/ijpvm.IJPVM_298_17.</mixed-citation><mixed-citation xml:lang="en">Sharma P., Lalwani J., Pandey P., Thakur A. Factors Associated with the Development of Secondary Multidrug-resistant Tuberculosis // Int. J. Prev. Med. –2019. – Vol. 10. – P. 67. doi: 10.4103/ijpvm.IJPVM_298_17.</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Singh R., Dwivedi S., Gaharwar U., Meena R., Rajamani P., Prasad T. Recent updates on drug resistance in Mycobacterium tuberculosis // J. Appl. Microbiol. – 2020. – Vol. 128. – N. 6. – P. 1547-1567. doi: 10.1111/jam.14478.</mixed-citation><mixed-citation xml:lang="en">Singh R., Dwivedi S., Gaharwar U., Meena R., Rajamani P., Prasad T. Recent updates on drug resistance in Mycobacterium tuberculosis // J. Appl. Microbiol. – 2020. – Vol. 128. – N. 6. – P. 1547-1567. doi: 10.1111/jam.14478.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Ssengooba W., Nakayita G., Namaganda C., Joloba M. Agreement of Middle brook 7H10 with Lowenstein Jensen and accuracy of the Sensititre MYCOTB plate using either method as a reference standard for Mycobacterium tuberculosis first line drug susceptibility testing // PLoS One. – 2018. – Vol. 13. – N. 6: e0199638. doi: 10.1371/journal.pone.0199638.</mixed-citation><mixed-citation xml:lang="en">Ssengooba W., Nakayita G., Namaganda C., Joloba M. Agreement of Middle brook 7H10 with Lowenstein Jensen and accuracy of the Sensititre MYCOTB plate using either method as a reference standard for Mycobacterium tuberculosis first line drug susceptibility testing // PLoS One. – 2018. – Vol. 13. – N. 6: e0199638. doi: 10.1371/journal.pone.0199638.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Swain S., Sharma D., Hussain T., Pati S. Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis // Emerg. Microbes. Infect. – 2020. – Vol. 9. – N. 1. – P. 1651-1663. doi: 10.1080/22221751.2020.1785334.</mixed-citation><mixed-citation xml:lang="en">Swain S., Sharma D., Hussain T., Pati S. Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis // Emerg. Microbes. Infect. – 2020. – Vol. 9. – N. 1. – P. 1651-1663. doi: 10.1080/22221751.2020.1785334.</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Tahlan K., Wilson R., Kastrinsky D. et al. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2012. – Vol. 56. – N. 4. – P. 1797-1809. doi:10.1128/AAC.05708-11.</mixed-citation><mixed-citation xml:lang="en">Tahlan K., Wilson R., Kastrinsky D. et al. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis // Antimicrob. Agents. Chemother. – 2012. – Vol. 56. – N. 4. – P. 1797-1809. doi:10.1128/AAC.05708-11.</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Tiberi S., Buchanan R., Caminero J., Centis R., Arbex M., Salazar M. et al. The challenge of the new tuberculosis drugs // Presse Med. – 2017. – Vol. 46(2 Pt 2):e41-e51. doi: 10.1016/j.lpm.2017.01.016.</mixed-citation><mixed-citation xml:lang="en">Tiberi S., Buchanan R., Caminero J., Centis R., Arbex M., Salazar M. et al. The challenge of the new tuberculosis drugs // Presse Med. – 2017. – Vol. 46(2 Pt 2):e41-e51. doi: 10.1016/j.lpm.2017.01.016.</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Torrea G., Coeck N., Desmaretz C., Van De Parre T., Van Poucke T., Lounis N. et al. Bedaquiline susceptibility testing of Mycobacterium tuberculosis in an automated liquid culture system // J. Antimicrob. Chemother. – 2015. – Vol. 70. – N. 8. – P. 2300-2305. doi: 10.1093/jac/dkv117.</mixed-citation><mixed-citation xml:lang="en">Torrea G., Coeck N., Desmaretz C., Van De Parre T., Van Poucke T., Lounis N. et al. Bedaquiline susceptibility testing of Mycobacterium tuberculosis in an automated liquid culture system // J. Antimicrob. Chemother. – 2015. – Vol. 70. – N. 8. – P. 2300-2305. doi: 10.1093/jac/dkv117.</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Torrea G., Ng K., Van Deun A., André E., Kaisergruber J. et al. A comparison of the Sensititre® MYCOTB panel and the agar proportion method for the susceptibility testing of Mycobacterium tuberculosis // Sci. Rep. – 2019. – Vol. 9. – N. 1: 11826. doi: 10.1038/s41598-019-48401-z.</mixed-citation><mixed-citation xml:lang="en">Torrea G., Ng K., Van Deun A., André E., Kaisergruber J. et al. A comparison of the Sensititre® MYCOTB panel and the agar proportion method for the susceptibility testing of Mycobacterium tuberculosis // Sci. Rep. – 2019. – Vol. 9. – N. 1: 11826. doi: 10.1038/s41598-019-48401-z.</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Tortoli E., Benedetti M., Fontanelli A., Simonetti M. Evaluation of automated BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to four major antituberculous drugs: comparison with the radiometric Bactec 460TB method and the agar plate method of proportion // J. Clin. Microbiol. – 2002. – Vol. 40. – N. 2. – P. 607-610. doi: 10.1128/jcm.40.2.607-610.2002.</mixed-citation><mixed-citation xml:lang="en">Tortoli E., Benedetti M., Fontanelli A., Simonetti M. Evaluation of automated BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to four major antituberculous drugs: comparison with the radiometric Bactec 460TB method and the agar plate method of proportion // J. Clin. Microbiol. – 2002. – Vol. 40. – N. 2. – P. 607-610. doi: 10.1128/jcm.40.2.607-610.2002.</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Van Deun A., Aung K., Hossain A., de Rijk P., Gumusboga M., Rigouts L., de Jong B. Disputed rpoB mutations can frequently cause important rifampicin resistance among new tuberculosis patients // Int. J. Tuberc. Lung. Dis. – 2015. – Vol. 19. – N. 2. – P. 185-190.</mixed-citation><mixed-citation xml:lang="en">Van Deun A., Aung K., Hossain A., de Rijk P., Gumusboga M., Rigouts L., de Jong B. Disputed rpoB mutations can frequently cause important rifampicin resistance among new tuberculosis patients // Int. J. Tuberc. Lung. Dis. – 2015. – Vol. 19. – N. 2. – P. 185-190.</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Warrier T., Kapilashrami K., Argyrou A., Ioerger T., Little D., Murphy K. et al. N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis // P. Natl. Acad. Sci USA. – 2016. – Vol. 113. – N. 31. – E4523-30.</mixed-citation><mixed-citation xml:lang="en">Warrier T., Kapilashrami K., Argyrou A., Ioerger T., Little D., Murphy K. et al. N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis // P. Natl. Acad. Sci USA. – 2016. – Vol. 113. – N. 31. – E4523-30.</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Wei J., Dahl J., Moulder J., Roberts E., O’Gaora P., Young D., Friedman R. Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages // J. Bacteriol. – 2000. – Vol. 182. – N. 2. – P. 377–384.</mixed-citation><mixed-citation xml:lang="en">Wei J., Dahl J., Moulder J., Roberts E., O’Gaora P., Young D., Friedman R. Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages // J. Bacteriol. – 2000. – Vol. 182. – N. 2. – P. 377–384.</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. 2013. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF assay for the: diagnosis of pulmonary and extrapulmonary TB in adults and children. Policy update. – WHO.: Geneva, Switzerland, 2013.</mixed-citation><mixed-citation xml:lang="en">WHO. 2013. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF assay for the: diagnosis of pulmonary and extrapulmonary TB in adults and children. Policy update. – WHO.: Geneva, Switzerland, 2013.</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. 2014. Сompanion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis. Chapter 3. Laboratory. – Geneva: WHO, 2014.− P. 39-60.</mixed-citation><mixed-citation xml:lang="en">WHO. 2014. Сompanion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis. Chapter 3. Laboratory. – Geneva: WHO, 2014.− P. 39-60.</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Global tuberculosis report 2015. – Geneva Google Scholar, 2016.</mixed-citation><mixed-citation xml:lang="en">WHO. Global tuberculosis report 2015. – Geneva Google Scholar, 2016.</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. The use of molecular line probe assays for the detection of resistance to second-line antituberculosis drugs. Policy guidance. – Geneva, Switzerland:</mixed-citation><mixed-citation xml:lang="en">WHO. The use of molecular line probe assays for the detection of resistance to second-line antituberculosis drugs. Policy guidance. – Geneva, Switzerland:</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Technical report on critical concentrations for drug susceptibility testing of medicines used in the treatment of drug-resistant tuberculosis. WHO/CDS/TB/2018a.5. – Geneva, 2018.</mixed-citation><mixed-citation xml:lang="en">WHO. Technical report on critical concentrations for drug susceptibility testing of medicines used in the treatment of drug-resistant tuberculosis. WHO/CDS/TB/2018a.5. – Geneva, 2018.</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Technical manual for drug susceptibility testing of medicines used in the treatment of tuberculosis. – World Health Organization. 2018b; WHO/CDS/TB/2018.24.</mixed-citation><mixed-citation xml:lang="en">WHO. Technical manual for drug susceptibility testing of medicines used in the treatment of tuberculosis. – World Health Organization. 2018b; WHO/CDS/TB/2018.24.</mixed-citation></citation-alternatives></ref><ref id="cit119"><label>119</label><citation-alternatives><mixed-citation xml:lang="ru">Wilby K., Hussain F., A Review of clinical pharmacokinetic and pharmacodynamic relationships and clinical implications for drugs used to treat multi-drug resistant tuberculosis // Eur. J. Drug. Metab. Pharmacokinet. – 2020. – Vol. 45. – P. 305-313. https://doi.org/10.1007/s13318-019-00604-5.</mixed-citation><mixed-citation xml:lang="en">Wilby K., Hussain F., A Review of clinical pharmacokinetic and pharmacodynamic relationships and clinical implications for drugs used to treat multi-drug resistant tuberculosis // Eur. J. Drug. Metab. Pharmacokinet. – 2020. – Vol. 45. – P. 305-313. https://doi.org/10.1007/s13318-019-00604-5.</mixed-citation></citation-alternatives></ref><ref id="cit120"><label>120</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y., Yew W.-W. Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015 // Int. J. Tuberc. Lung. Dis. – 2015. – Vol. 19. – N. 11. – P. 1276-1289.</mixed-citation><mixed-citation xml:lang="en">Zhang Y., Yew W.-W. Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015 // Int. J. Tuberc. Lung. Dis. – 2015. – Vol. 19. – N. 11. – P. 1276-1289.</mixed-citation></citation-alternatives></ref><ref id="cit121"><label>121</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Z., Pang Y., Wang Y., Liu C., Zhao Y. Beijing genotype of Mycobacterium tuberculosis is significantly associated with linezolid resistance in multidrug-resistant and extensively drug-resistant tuberculosis in China // Int. J. Antimicrob. Agents. – 2014. – Vol. 43. – N. 3. – P. 231-235. 2013.12.007.</mixed-citation><mixed-citation xml:lang="en">Zhang Z., Pang Y., Wang Y., Liu C., Zhao Y. Beijing genotype of Mycobacterium tuberculosis is significantly associated with linezolid resistance in multidrug-resistant and extensively drug-resistant tuberculosis in China // Int. J. Antimicrob. Agents. – 2014. – Vol. 43. – N. 3. – P. 231-235. 2013.12.007.</mixed-citation></citation-alternatives></ref><ref id="cit122"><label>122</label><citation-alternatives><mixed-citation xml:lang="ru">Zignol M., Dara M., Dean A. et al. Drug-resistant tuberculosis in the WHO European Region: an analysis of surveillance data // Drug. Resist. Updat. – 2013. – Vol. 16. – N. 6. – P. 108-115.</mixed-citation><mixed-citation xml:lang="en">Zignol M., Dara M., Dean A. et al. Drug-resistant tuberculosis in the WHO European Region: an analysis of surveillance data // Drug. Resist. Updat. – 2013. – Vol. 16. – N. 6. – P. 108-115.</mixed-citation></citation-alternatives></ref><ref id="cit123"><label>123</label><citation-alternatives><mixed-citation xml:lang="ru">Zimenkov D., Nosova E., Kulagina E., Antonova O., Arslanbaeva L., Isakova A. et al. Examination of bedaquiline- and linezolid-resistant Mycobacterium tuberculosis isolates from the Moscow region // J. Antimicrob. Chemother. – 2017. – Vol. 72. – N. 7. – P. 1901-1906. doi: 10.1093/jac/dkx094.</mixed-citation><mixed-citation xml:lang="en">Zimenkov D., Nosova E., Kulagina E., Antonova O., Arslanbaeva L., Isakova A. et al. Examination of bedaquiline- and linezolid-resistant Mycobacterium tuberculosis isolates from the Moscow region // J. Antimicrob. Chemother. – 2017. – Vol. 72. – N. 7. – P. 1901-1906. doi: 10.1093/jac/dkx094.</mixed-citation></citation-alternatives></ref><ref id="cit124"><label>124</label><citation-alternatives><mixed-citation xml:lang="ru">Zürcher K., Ballif M., Fenner L. et al. Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicenter cohort study. International epidemiology Databases to Evaluate AIDS (IeDEA) consortium // Lancet Infect. Dis. – 2019. – Vol. 19. – N. 3. – P. 298-307.</mixed-citation><mixed-citation xml:lang="en">Zürcher K., Ballif M., Fenner L. et al. Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicenter cohort study. International epidemiology Databases to Evaluate AIDS (IeDEA) consortium // Lancet Infect. Dis. – 2019. – Vol. 19. – N. 3. – P. 298-307.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
