References

tbjournal

Туберкулез и социально значимые заболевания

Tuberculosis and socially significant diseases

2413-03462413-0354

ООО «Ин-Тренд

tbjournal-327

Research Article

АКТУАЛЬНЫЕ ПРОБЛЕМЫ ФТИЗИАТРИИ

«Дремлющие» микобактерии, дормантные локусы, латентная туберкулезная инфекция

«DORMANT» MYCOBACTERIA, DORMANT LOCI, LATENT TUBERCULOSIS INFECTION

Литвинов

В. И.

Litvinov

V. I.

Литвинов Виталий Ильич – научный руководитель ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы», доктор медицинских наук, профессор, академик РАН

107014, г. Москва, ул. Стромынка, д. 10Тел.: +7 (499) 268-04-15

mnpcbtlv@yandex.ru

ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»Russian Federation

2016

28012025

02513

2025

Литвинов В.И.

Litvinov V.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.tb-journal.ru/jour/article/view/327

Обзор посвящен описанию исследований, характеризующих современное состояние проблемы латентной туберкулезной инфекции. Особое внимание уделено описанию особенностей возбудителя в латентном («дремлющем») состоянии и реакции макроорганизма на «дремлющие» микобактерии (дормантные локусы, реакции макрофагов и др.).

The review is dedicated to the description of studies that characterized the current state of the problem of latent TB infection. Particular attention is paid to the description of features of the pathogen in a latent («dormant») state and response of host organism to «dormant» mycobacteria (dormant loci, the reaction of macrophages and others).

латентная туберкулезная инфекция«дремлющие» микобактериидормантные локусы

latent TB infectiondormant mycobacteriadormant loci

References1

Земскова З.С., Дорожкова И.Р. Скрыто протекающая туберкулезная инфекция. // М.: Медицина, 1984. – 224 с.

Литвинов В.И. Латентная туберкулезная инфекция – миф или реальность? // Туберкулез и болезни легких. – 2011. – № 6. – С. 3-9.

Литвинов В.И. Латентная туберкулезная инфекция – свойства возбудителя; реакции макроорганизма; эпидемиология и диагностика (IGRA-тесты, ДИАСКИНТЕСТ® и другие подходы), лечение. – М.: МНПЦБТ. – 2016. – 196 с.

Митинская Л.А. Туберкулез у детей. – М.: ЗАО «Кудесники», 2004. – 196 с.

Скворцов Т.А., Ажикина Т.Л. Адаптивные изменения экспрессии генов Mycobacterium tuberculosis в ходе инфекционного процесса. // Биоорг. химия. – 2012. – Т. 38. – С. 391-405.

Слогоцкая Л.В., Сенчихина О.Ю., Никитина Г.В., Богородская Е.М. Эффективность кожного теста с аллергеном туберкулезным рекомбинантным при выявлении туберкулеза у детей и подростков Москвы в 2013 г. // Педиатрическая фармакология. – 2015. – № 1. – С. 99-103.

Ahmad S. Pathogenesis, immunology, and diagnosis of latent Mycobacterium tuberculosis infection. // Clin. Dev. Immunol. – 2011. – P. 814-943.

Al-Orainey I. Diagnosis of latent tuberculosis: Can we do better? // Ann. Thorac. Med. – 2009. – Vol. 4. – N. 1. – P. 5-9.

Andersen P., Munk M., Pollock J. et al. Specific immune-based diagnosis of tuberculosis. // Lancet. – 2000. – Vol. 356. – P. 1099-1104.

Barry C., Boshoff H., Dartois V. et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. // Nat. Rev. Microbiol. – 2009. – Vol. 7. – N. 12. – P. 845-855.

Belay M., Legesse M., Mihret A. et al. Pro- and anti-inflammatory cytokines against Rv2031 are elevated during latent tuberculosis: a study in cohorts of tuberculosis patients, household contacts and community controls in an endemic setting. // PLoS One. – 2015. – Vol. 10. – N. 4. – e0124134.

Capuano S., Croix D., Pawar S. et.al. Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection // Infect. Immun. – 2003. – Vol. 71. – N. 10. – P. 5831-5844

Casey R., Blumenkrantz D., Millington K. et al. Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis. // PLoS One. – 2010. – Vol. 5. – N. 12. – e15619.

Chao M., Rubin E. Letting sleeping dos lie: does dormancy play a role in tuberculosis?// Ann. Rev. Microbiol. – 2010. – Vol. 64. – P. 293-311.

Cole S., Brosch R., Parkhill J. et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. // Nature. – 1998. – Vol. 393. – P. 537-544.

Commandeur S., van Meijgaarden K., Prins C. et.al. An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T-cells expressed during pulmonary infection // J. Immunol. – 2013. – Vol. 190. – N. 4. – P. 1659-1671.

Corbière V., Pottier G., Bonkain F. et al. Risk stratification of latent tuberculosis defined by combined interferon gamma release assays. // PLoS One. – 2012. – Vol. 7. – N. 8. – e43285.

Demissie A., Leyten E.M., Abebe M. et al. Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis // Clin. Vaccine Immunol. – 2006. – Vol. 13. – N. 2. – P. 179-186.

Dheda K., Schwander S., Zhu B. et al. The immunology of tuberculosis: from bench to bedside. // Respirology. – 2010. – Vol. 15. – P. 433–450.

Diel R., Goletti D., Ferrara G. et al. Interferon-γ release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis. // Eur. Respir. J. – 2011. – Vol. 37. – N. 1. – P. 88-99.

Ernst J. The immunological life cycle of tuberculosis // Nat. Rev. Immunol. – 2012. – Vol. 12. – N. 8. – P. 581-591.

Esmail H., Barry E., Wilkinson R. Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies. // Drug. Discov. Today. – 2012. – Vol. 17. – N. 9-10. – P. 514-521.

Garton N., Waddell S., Sherratt A. et al. Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum // PLoS Med. – 2008. – Vol. 5. – N. 4. – e75.

Govender L., Abel B., Hughes E. et al. Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease. // Vaccine. – 2010. – Vol. 29. – N. 1. – P. 51-57.

Harari A., Rozot V., Bellutti Enders F. et al. Dominant TNF-alpha(+) Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. // Nat. Med. – 2011. – Vol. 17. – N. 3. – P. 372-376.

Harboe M., Oettinger T., Wiker H. et al. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. // Infect. Immun. – 1996. – Vol. 64. – N. 1. – P. 16-22.

Hinks T., Dosanjh D., Innes J. et al. Frequencies of region of difference 1 antigen-specific but not purified protein derivative-specific gamma interferon-secreting T cells correlate with the presence of tuberculosis disease but do not distinguish recent from remote latent infections. // Infect. Immun. – 2009. – Vol. 77. – N. 12. – P. 5486-5495.

Horsburgh C. Priorities for the treatment of latent tuberculosis infection in the United States. // N. Engl. J. Med. – 2004. – Vol. 350. – N. 20. – P. 2060-2067.

Johnson P., Stuart R., Grayson M. et.al. Tuberculin-purified protein derivative-, MPT-64-, and ESAT-6-stimulated gamma interferon responses in medical students before and after Mycobacterium bovis BCG vaccination and in patients with tuberculosis // Clin. Diagn. Lab. Immunol. – 1999. – Vol. 6. – N. 6. – P. 934-937.

Kunnath-Velayudhan S., Gennaro M. Immunodiagnosis of tuberculosis: a dynamic view of biomarker discovery. // Clin. Microbiol. Rev. – 2011. – Vol. 24. – N. 4. – P. 792-805.

Lalvani A., Pareek M. A 100 year update on diagnosis of tuberculosis infection. // Br. Med. Bull. – 2010. – Vol. 93. – P. 69-84.

Lawn S., Wood R., Wilkinson R. Changing concepts of «latent tuberculosis infection» in patients living with HIV infection. // Clin. Dev. Immunol. – 2011: pii: 980594.

Lin P., Rodgers M., Smith L. et al. Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. // Infect. and Immun. – 2009. – Vol. 77. – N. 10. – P. 4631-4642.

Mack U., Migliori G., Sester M. et al. LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. // Eur. Respir. J. – 2009. – Vol. 33. – P. 956-973.

Mazurek G., Jereb J., Vernon A. et al. Updated guidelines for using interferon gamma release Assays to detect Mycobacterium tuberculosis infection. // MMWR Recomm. Rep. – 2010. – Vol. 59. – P. 1-25.

Menzies D., Pai M., Comstock G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. // Ann. Intern. Med. – 2007. – Vol. 146. – P. 340-354.

Millington K., Innes J., Hackforth S. et al. Dinamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load. // J. Immunol. – 2007. – Vol. 178. – N. 8. – P. 5217-5226.

Millington K., Fortune S., Low J. et al. Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection. // Proc. Natl. Acad. Sci. USA. – 2011. – Vol. 108. – N. 14. – P. 5730-5735.

Mori T., Sakatani M., Yamagishi F. et al. Specific detection of tuberculosis infection: An interferon-gamma-based assay using new antigens. // Am. J. Respir. Crit. Care Med. – 2004. – Vol. 170. – P. 59-64.

Pai M., Kalantri S., Dheda K. New tools and emerging technologies for the diagnosis of tuberculosis: part I. Latent tuberculosis. // Expert. Rev. Mol. Diagn. – 2006. – Vol. 6. – P. 413-422.

Park H., Guinn K., Harrell M. et al. Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. // Mol. Microbiol. – 2003. – Vol. 48. – P. 833-843.

Peyron P., Vaubourgeix J., Poquet Y. et.al. Foamy macrophages from tuberculous patients’ granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence // PLoS. Pathog. – 2008. – Vol. 4. – N. 11. – e1000204.

Rangaka M., Diwakar L., Seldon R. et al. Clinical, Immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans. // Clin. Infect. Dis. – 2007. – Vol. 44. – P. 1639-1646.

Rangaka M., Wilkinson K., Glynn J. et al. Predictive value of interferon-γ release assay for incident active tuberculosis: a systematic review and meta-analysis // Lancet Infect. Dis. – 2012. – Vol. 12. – N. 1. – P. 45-55.

Rieder H. Socialization patterns are key to the transmission dynamics of tuberculosis // Int. J. Tuberc. Lung. Dis. – 1999. – Vol. 3. – N. 3. – P. 177-178.

Rueda C., Martin N., Garcia L., Rojas M. Characterization of CD4 and CD8 T cells producing INF-gamma in human latent and active tuberculosis // Tuberculosis (Edinb). – 2010. – Vol. 90. – N. 6. – P. 346-353.

Russell D., Cardona P., Kim M. et al. Foamy macrophages and the progression of the human tuberculosis granuloma // Nat. Immunol. – 2009. – Vol. 10. – N. 9. – P. 943-948.

Rustad T., Harrell M., Liao R. Sherman D. The enduring hypoxic response of Mycobacterium tuberculosis. In: The immunological life cycle of tuberculosis // Nat. Rev. Immunol. – 2012. – Vol. 12. – N. 8. – P. 581-591.

Sargentini V., Mariotti S., Carrara S. et al Cytometric detection of antigen-specific INF-gamma/IL-2 secreting cells in the diagnosis of tuberculosis. // BMC Infect. Dis. – 2009. – Vol. 9. – P. 99.

Schluger N., Burzynski J. Recent advances in testing for latent TB. // Chest. – 2010. – Vol. 138. – N. 6. – P. 1456-1463.

Schnappinger D., Ehrt S., Voskuil M. et al. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment // J. Exp. Med. – 2003. – Vol. 198. – N. 5. – P. 693-704.

Schuck S., Mueller H., Kunitz F. et.al. Identification of T-cell antigens specific for latent Mycobacterium tuberculosis infection // PLoS One. – 2009. – Vol. 4. – N. 5. – e5590.

Serra-Vidal M., Latorre I., Franken K. et al. Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis. // Front. Microbiol. – 2014. – Vol. 5. – P. 517.

Sester M., Sotqiu G., Lanqe C. et al. Interferon-gamma release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. // Eur. Respir. J. – 2011. – Vol. 37. – N. 1. – P. 100-111.

Vekemans J., Lienhardt C., Sillah J. et al. Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia. // Infect. Immun. – 2001. – Vol. 69. – N. 10. – P. 6554-6557.

Wallis R., Pai M., Menzies D. et al. Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice. // Lancet. – 2010. – Vol. 375. – P. 1920-1937.

Wergeland I., Assmus J., Dyrhol-Riise A. et al. T regulatory cells and immune activation in Mycobacterium tuberculosis infection and effect of preventive therapy. // Scand. J. Immunol. – 2010. – Vol. 73. – N. 3. – P. 234-242.

Wyndham-Thomas C., Corbière V., Dirix V. et al. Key role of effector memory CD4+ T lymphocytes in a short-incubation heparin-binding hemagglutinin gamma interferon release assay for the detection of latent tuberculosis // Clin. Vaccine Immunol. – 2014. – Vol. 21. – N. 3. – P. 321-328.

Zhang T., Li S., Williams K. et al. Short-course chemotherapy with TMC207 and rifapentine in a murine model of latent tuberculosis infection // Am. J. Respir. Crit. Care Med. – 2011. – Vol. 184. N. 6. – P. 732-737.

The authors declare that there are no conflicts of interest present.