tbjournalТуберкулез и социально значимые заболеванияTuberculosis and socially significant diseases2413-03462413-0354ООО «Ин-Трендtbjournal-497Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWЛекарственная устойчивость микобактерий: эпидемиологияDrug resistance of mycobacteria: epidemiologyЛитвиновВ. И.LitvinovV. I.

Литвинов Виталий Ильич – научный руководитель ГБУЗ города Москвы «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы», доктор медицинских наук, профессор, академик РАН

107014, г. Москва, ул. Стромынка, д. 10Тел.: 8 (495) 268-04-15

mnpcbtlv@yandex.ruНосоваЕ. Ю.NosovaE. Yu.

Носова Елена Юрьевна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии ГБУЗ города Москвы «Московский городской научно-практический центр борьбы с туберкулезомДепартамента здравоохранения города Москвы», кандидат медицинских наукАдрес:

107014, г. Москва, ул. Стромынка, д.10Тел.: 8 (495) 603-30-33

rna68@rambler.ruМакароваМ. В.MakarovaM. V.

Макарова Марина Витальевна – главный научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии ГБУЗ города Москвы «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы», доктор биологических наук

107014, г. Москва, ул. Стромынка, д. 10Тел.: +7 (916) 688-98-25

makarova75@yandex.ruКрасноваМ. А.KrasnovaM. A.

Краснова Мария Александровна – ведущий научный сотрудник отдела проблем лабораторной диагностики туберкулеза и патоморфологии ГБУЗ города Москвы «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы», кандидат медицинских наук

107014, г. Москва, ул. Стромынка, д. 10Тел.: 8 (495) 603-30-33

dna77@mail.ruСиницынМ. В.SinitsinM. V.

Синицын Михаил Валерьевич – и. о. директора ГБУЗ города Москвы «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы», кандидат медицинских наук

107014, г. Москва, ул. Стромынка, д. 10, стр. 1Тел.: 8 (499) 268-00-05

msinitsyn@mail.ruБелиловскийЕ. М.BelilovskyE. M.

Белиловский Евгений Михайлович – заведующий отделом эпидемиологического мониторинга туберкулеза ГБУЗ города Москвы «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы», кандидат биологических наук

107014, г. Москва, ул. Барболина, д. 3, корп. 3Тел.: +7 (915) 190-90-10

belilo5@mail.ruБогородскаяЕ. М.BogorodskayaE. M.

Богородская Елена Михайловна – профессор кафедры фтизиатрии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, доктор медицинских наук

107014, г. Москва, ул. Стромынка, д. 10, стр. 10Тел.: +7 (925) 381-02-18

El_bogorodskaya@mail.ruГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»Russian FederationГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»Russian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииRussian Federation201905022025034266Copyright © Литвинов В.И., Носова Е.Ю., Макарова М.В., Краснова М.А., Синицын М.В., Белиловский Е.М., Богородская Е.М., 20252025Литвинов В.И., Носова Е.Ю., Макарова М.В., Краснова М.А., Синицын М.В., Белиловский Е.М., Богородская Е.М.Litvinov V.I., Nosova E.Y., Makarova M.V., Krasnova M.A., Sinitsin M.V., Belilovsky E.M., Bogorodskaya E.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tb-journal.ru/jour/article/view/497

В обзоре представлены современные литературные данные о механизмах лекарственной устойчивости микобактерий туберкулеза (МБТ) и нетуберкулезных микобактерий (НТМБ) и о распространении туберкулеза с лекарственной устойчивостью в странах мира и регионах России, включая город Москву, в различных возрастных и социальных группах пациентов, среди впервые выявленных и ранее пролеченных больных. Описаны спектры лекарственной устойчивости МБТ в различных странах и при различных сполиготипах, а также приведены данные о лекарственной устойчивости быстро- и медленнорастущих НТМБ, полученные в городе Москве.

Review include the current data on Mycobacterium tuberculosis (MBT) and non-tuberculosis mycobacteria (NTMB) drug resistance mechanisms, on the spread of drug-resistant tuberculosis in world countries and Russian regions (include Moscow), in different ageand social groups, in new and in retreatment cases. Described the drug-resistance spectrum of MBT in world countries and in various spoligotypes, as well as data on drug resistance of fast and slowly growing NTMB, isolated in Moscow.

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The authors declare that there are no conflicts of interest present.