Experience of the recombinant tuberculosis allergen as a scree ning tool for pediatric tuberculosis in the Sakha Re public (Yakutia)

Abstract

Pediatric population of the Tulagino-Kildyamsky rural settlement under jurisdiction of the Yakutsk city (802 children and adolescents) was screened for tuberculosis (TB), using Mantoux skin test with 2 TU PPD-L and skin test with recombinant tuberculosis allergen (Diaskintest®). Simultaneous administration of Diaskintest® with Mantoux skin test allowed accurate selection of children and adolescents at high risk for TB. Comparative analysis of the test results showed that use of Diaskintest® substantially reduced the number of
children and adolescents with positive responses eligible for further examination by a TB doctor and for preventive therapy.