Drug susceptibility patterns of clinical fungal strains, which cause cryptococcosis and rare yeast infections, isolated in a TB hospital
Abstract
We determined the levels of drug susceptibility of clinical strains of yeasts of the genera Cryptococcus (two species), Geotrichum (one species), Hanseniaspora (one species), Saccharomyces (one species), Saprochaete (one species), Rhodotorula (two species), isolated at diagnosing bronchopulmonary mycoses and central nervous system cryptococcosis. We established that amphotericin B and voriconazole were most active against fungi, which caused advanced mycoses. Susceptibility to triazoles correlated with strain species; low susceptibility to all triazoles was typical for Rhodotorula spp. Echinocandins activity was high against the ascomycetes (Geotrichum, Hanseniaspora, Saccharomyces, Saprochaete) and low against the basidiomycetes (Cryptococcus, Rhodotorula). We recommend performing in vitro susceptibility tests to major antimycotics for causative agents of cryptococcosis and rare yeast infections based on the established levels of initial susceptibility.
About the Authors
A. B. Kulko
ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
S. G. Safonova
ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
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Review
For citations:
Kulko A.B., Safonova S.G. Drug susceptibility patterns of clinical fungal strains, which cause cryptococcosis and rare yeast infections, isolated in a TB hospital. Tuberculosis and socially significant diseases. 2019;(1):32-36. (In Russ.)
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