The use of laboratory immunological tests for the study of pleural fluid in the diagnosis of tuberculous pleurisy
Abstract
The article describes the experience of use and diagnostic value of T-SPOT®.TB test system in the study of peripheral blood and pleural fluid in patients with suspected tuberculous pleurisy in the presence of effusion in the pleural cavity. It was shown that the analysis of pleural fluid can increase the clinical sensitivity of the test system to 91.3% (95% CI 83.8-95.5%) compared with the analysis of peripheral blood (83.7%, 95% CI 74.8- 89.75; p = 0.04). The prognostic value of a negative test result is 1.3 times higher when using pleural fluid compared with a study of peripheral blood. At the same time, good consistency of laboratory test results in the study of peripheral blood and pleural fluid (κ = 0.6; p = 0.005) and equivalent diagnostic efficacy and specificity of the test, as well as the prognostic value of a positive result, were demonstrated. It was found that the frequency of positive test results among patients with pleural effusion of tuberculous etiology does not depend on the HIV status of the patient.
About the Authors
T. Vaneeva
ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом
Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
T. Abu-Arkub
ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
N. Kulikovskaya
ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
M. Sinitsyn
ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
S. Safonova
ГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
D. A. Kudlay
ФГБУ «ГНЦ Институт иммунологии» ФМБА России
Russian Federation
Russian Federation
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Review
For citations:
Vaneeva T., Abu-Arkub T., Kulikovskaya N., Sinitsyn M., Safonova S., Kudlay D.A. The use of laboratory immunological tests for the study of pleural fluid in the diagnosis of tuberculous pleurisy. Tuberculosis and socially significant diseases. 2019;(3):17-22. (In Russ.)
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