Features of oncological comorbidity in tuberculosis patients
https://doi.org/10.54921/2413-0346-2025-13-2-19-24
Abstract
Aim. To determine the place and structure of malignancies in tuberculosis patients.
Material and methods. The retrospective study used the data of the regional epidemiological system of TB monitoring, reporting forms № 33 for 2018–2024. During this time 157 TB patients aged ≥18 years with concomitant oncopathology were discharged from the Moscow Research and Clinical Center for Tuberculosis Control. Among them there were 106 (67.5%) men and 51 (32.5%) women.
Results. Cancer in TB patients was 2-fold more common in men (67.5%) than in women (32.5%), occurring in 63.2% (67 out of 106) of cases between the ages of 51–70 years in men and in 55.4% among all patients (87 out of 157). The main clinical form of TB was infiltrative (47.1%), less frequently tuberculoma (10.8%), disseminated (7.0%) and fibrotic cavernous TB (6.4%). The genitourinary system (39.5%) was the most frequently affected by cancer processes, the organs of the digestive (17.8%) and respiratory (16.4%) systems were less frequently affected. The combination of cancer and TB in the same organ system was found in 25 (16.6%) of 151 lung TB patients and in 2 (5.9%) of 34 kidney TB patients. The overwhelming majority (91.1%) of patients had active TB in various combinations: respiratory TB in 86.6%, extrapulmonary TB in 1.9%, combined respiratory and extrapulmonary TB in 1.3%, and active extrapulmonary TB with a history of cured respiratory TB in 1.3%.
Conclusion. The peak incidence of TB/cancer combined pathology is at the age of 51–70 years mainly due to men. The structure of oncological pathology in TB patients is dominated by tumors of extrapulmonary localization with predominance of neoplasms of genitourinary, digestive and respiratory organs.
About the Authors
O. N. Zuban
Moscow Research and Clinical Center for Tuberculosis Control of Moscow Government Department of Health ; Russian Medical Academy of Postgraduate Education
Россия
Россия
Moscow
V. B. Avdentova
Moscow Research and Clinical Center for Tuberculosis Control of Moscow Government Department of Health ; Russian Medical Academy of Postgraduate Education
Россия
Россия
Moscow
Yu. R. Sikaev
Moscow Research and Clinical Center for Tuberculosis Control of Moscow Government Department of Health
Россия
Россия
Moscow
References
1. Иванова Д.А., Белиловский Е.М., Богородская Е.М. и др. Влияние сопутствующей патологии на исходы лечения больных туберкулезом // Терапевтический архив. – 2024. – Т. 96. – № 8. – C. 790-796. doi: 10.26442/00403660.2024.08.202812.
2. Новицкая Т.А., Ариэль Б.М., Двораковская И.В. и др. Морфологические особенности сочетания туберкулеза и рака легких // Архив патологии. – 2021. – Т. 83. – № 2. – С. 19-24.
3. Холтобин Д.П., Кульчавеня Е.В., Хомяков, В.Т. Рак и туберкулез мочеполовой системы (обзор литературы и клиническое наблюдение) // Урология. – 2016. – № 4. – С. 106-109.
4. Эпидемиология, профилактика и лечение туберкулеза в г. Москве, 2022 г. / Под ред. Е.М. Богородской. – М.: МНПЦБТ, 2023. – 294 с.
5. Basham C.A., Smith S.J., Romanowski K., Johnston J.C. Cardiovascular morbidity and mortality among persons diagnosed with tuberculosis: a systematic review and meta-analysis // PLoS One. – 2020. – Vol. 15. – № 7. – P. e0235821. https://doi.org/10.1371/journal.pone.0235821 pmid:32649721
6. Byrne A.L., Marais B.J., Mitnick C.D. et al. Tuberculosis and chronic respiratory disease: a systematic review // Int. J. Infect. Dis. – 2015. – Vol. 32. – P. 138-146. https://www.sciencedirect.com/science/article/pii/S1201971214017330 pmid:25809770
7. Dodd P.J., Yuen C.M., Jayasooriya S.M. et al. Quantifying the global number of tuberculosis survivors: a modelling study // Lancet Infect. Dis. – 2021. – Vol. 21, № 7. – P. 984-992. https://www.sciencedirect.com/science/article/pii/S1473309920309191
8. Hoger S., Lykens K., Beavers S.F. et al. Longevity loss among cured tuberculosis patients and the potential value of prevention // Int. J. Tuberc. Lung Dis. – 2014. – Vol. 18, № 11. – P. 1347-1352. https://pubmed.ncbi.nlm.nih.gov/25299869 pmid:25299869
9. Lönnroth K., Jaramillo E., Williams B.G. et al. Drivers of tuberculosis epidemics: the role of risk factors and social determinants // Soc. Sci. Med. – 2009. – Vol. 68, № 12. – P. 2240-2246. https://www.sciencedirect.com/science/article/pii/S0277953609002111
10. Luczynski P., Poulin P., Romanowski K., Johnston J.C. Tuberculosis and risk of cancer: a systematic review and meta-analysis // PLoS One. – 2022. – Vol. 17, № 12. – P. e0278661. doi: 10.1371/journal.pone.0278661
11. de Martel C., Georges D., Bray F. et al. Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis // Lancet Glob. Heal. – 2020. – Vol. 8, № 2. – P. e180-190. https://doi.org/10.1016/S2214-109X(19)30488-7
12. Romanowski K., Baumann B., Basham C.A. et al. Long-term all-cause mortality in people treated for tuberculosis: a systematic review and meta-analysis // Lancet Infect. Dis. – 2019. – Vol. 19, № 10. – P. 1129-1137. https://doi.org/10.1016/S1473-3099(19)30309-3
13. Shu C.C., Liao K.M., Chen Y.C. et al. The burdens of tuberculosis on patients with malignancy: incidence, mortality and relapse // Sci. Rep. – 2019. – Vol. 9. – P. 11901. https://doi.org/10.1038/s41598-019-48395-8
14. Uplekar M., Weil D., Lonnroth K. et al. WHO’s new End TB Strategy // Lancet. – 2015. – Vol. 385, № 9979. – P. 1799-1801. https://doi.org/10.1016/S0140-6736(15)60570-0
15. Vento S., Lanzafame M. Tuberculosis and cancer: a complex and dangerous liaison // Lancet Oncol. – 2011. – Vol. 12, № 6. – P. 520-522. http://europepmc.org/abstract/MED/21624773
16. World Health Organization. Global tuberculosis report 2024. – 2024. https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/tb-reports/global-tuberculosis-report-2024
Review
For citations:
Zuban O.N., Avdentova V.B., Sikaev Yu.R. Features of oncological comorbidity in tuberculosis patients. Tuberculosis and socially significant diseases. 2025;13(2):19-24. (In Russ.) https://doi.org/10.54921/2413-0346-2025-13-2-19-24
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