Preview

Tuberculosis and socially significant diseases

Advanced search

Features of tuberculosis treatment in people over 60 years of age

https://doi.org/10.54921/2413-0346-2025-13-3-37-43

Abstract

The aim was to study the features of tuberculosis treatment in patients over 60 years of age.

Materials and methods. The results of a prospective study of 76 tuberculosis patients over the age of 60 newly diagnosed in 2018-2023 in the Yaroslavl and Kostroma regions were analyzed. The study covered the period from the diagnosis of tuberculosis to the completion of the main course of treatment.

Results. All patients required inpatient anti-tuberculosis chemotherapy. Standard doses of anti-tuberculosis drugs were used in only 40% of patients. In most cases, dose reductions and individualized regimens were required. Adverse reactions occurred in 60.5% of cases, requiring discontinuation of anti-tuberculosis medications or treatment interruption. Clinical cure was observed in 80.9% of cases attributed to the development of individualized antituberculosis chemotherapy regimens, the application of pathogenetic treatment, including therapeutic nutrition.

About the Authors

O. G. Chelnokova
Yaroslavl State Medical University
Россия

Yaroslavl



N. V. Skripnik
Yaroslavl State Medical University
Россия

Yaroslavl



A. P. Dmitrieva
Yaroslavl Regional Clinical Tuberculosis Hospital
Россия

Yaroslavl



E. N. Porshneva
Yaroslavl Regional Clinical Tuberculosis Hospital
Россия

Yaroslavl



E. V. Borisova
Kostroma Tuberculosis Dispensary
Россия

Kostroma



References

1. Здравоохранение в России. 2023: Стат. сб. / Росстат. – М., 2023. – 179 с.

2. Клинические рекомендации «Старческая астения» // Министерство здравоохранения Российской Федерации. – М., 2024. [Электронный ресурс]. Режим доступа: URL: https://cr.minzdrav.gov.ru/preview-cr/613_2

3. Ресурсы и деятельность противотуберкулезных организаций Российской Федерации в 2022–2023 гг. / И.А. Васильева, С.А. Стерликов, В.В. Тестов и др. – М.: РИО ЦНИИОИЗ, 2024. – 95 с.

4. Шпрыков А.С., Сутягина Д.А., Долгова М.А. Туберкулез органов дыхания у лиц старше 70 лет: особенности течения и трудности диагностики // Туберкулез и болезни легких. – 2021. – Т. 99, № 6. – С. 39-42. doi: 10.21292/2075-1230-2021-99-6-39-42

5. Cruz-Hervert L.P., García-García L., Ferreyra-Reyes L. et al. Tuberculosis in ageing: high rates, complex diagnosis and poor clinical outcomes // Age Ageing. – 2012. – Vol. 41, № 4. – P. 488-495. doi:10.1093/ageing/afs028

6. Global tuberculosis report 2020. – Geneva: World Health Organization, 2020. – URL: https://www.who.int/publications/i/item/9789240013131.

7. Hase I., Toren K.G., Hirano H. et al. Pulmonary tuberculosis in older adults: increased mortality related to tuberculosis within two months of treatment initiation // Drugs Aging. – 2021. – Vol. 38, № 9. – P. 807-815. doi:10.1007/s40266-021-00880-4

8. Tuberculosis action plan for the WHO European Region 2023- 2030 / World Health Organization. – 2023. – URL: https://www.who.int/publications/i/item/9789289060240

9. Tuberculosis in Japan: Annual report 2022 / Japan Anti-Tuberculosis Association. – 2022.

10. Wu I.L., Chitnis A.S., Jaganath D. A narrative review of tuberculosis in the United States among persons aged 65 years and older // J. Clin. Tuberc. Other Mycobact. Dis. – 2022. – № 28. – P. 100321. doi: 10.1016/j.jctube.2022.100321


Review

For citations:


Chelnokova O.G., Skripnik N.V., Dmitrieva A.P., Porshneva E.N., Borisova E.V. Features of tuberculosis treatment in people over 60 years of age. Tuberculosis and socially significant diseases. 2025;13(3):37-43. (In Russ.) https://doi.org/10.54921/2413-0346-2025-13-3-37-43

Views: 9

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2413-0346 (Print)
ISSN 2413-0354 (Online)