Treatment of active and latent multidrug-resistant tuberculosis in children of the same family
https://doi.org/10.54921/2413-0346-2024-12-1-56-60
Abstract
An observation of the management of active and latent tuberculosis with multidrug resistance of the causative agent of the disease in children from the same family has been presented. The efficacy and safety of a short, fully oral chemotherapy regimen with the use of new and repurposed drugs in a child with active pulmonary tuberculosis has been demonstrated. During the preventive treatment of latent tuberculosis infection for six months no adverse reactions after taking levofloxacin were reported. In one case, preventive treatment of latent MDR-TB was not carried out due to co-pathology newly diagnosed before taking the drug.
About the Authors
E. I. Nikishova
Federal State Budgetary Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
T. I. Guryeva
Federal State Budgetary Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation;
State Budgetary Healthcare Institution of the Arkhangelsk region «Arkhangelsk Clinical Tuberculosis Dispensary»
Russian Federation
Russian Federation
N. A. Vlasova
State Budgetary Healthcare Institution of the Arkhangelsk region «Severodvinsk City Hospital № 1»
Russian Federation
Russian Federation
A. A. Markova
Federal State Budgetary Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Z. E. Jafarova
Federal State Budgetary Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. O. Maryandyshev
Federal State Budgetary Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
References
1. Клинические рекомендации «Туберкулез у детей» / Российское общество фтизиатров. – 2022. https://cr.minzdrav.gov.ru/recomend/507
2. Можокина Г.Н., Самойлова А.Г. Клофазимин: история и перспективы // Туберкулез и болезни легких. – 2021. – Т. 99. – № 5. – С. 64-70.
3. Сводное руководство ВОЗ по лечению лекарственно-устойчивого туберкулеза / Европейское региональное бюро ВОЗ. – Копенгаген, 2019. Режим доступа: https://iris.who.int/handle/10665/329298
4. Global tuberculosis report 2021. – Geneva: World Health Organization, 2021. Режим доступа: https://apps.who.int/iris/handle/10665/346387
5. Dodd P.J., Gardiner E., Coghlan R., Seddon J.A. Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study // Lancet Glob. Health. -2014. – Vol. 2, № 8. – P. e453-e459. DOI: 10.1016/S2214-109X(14)70245-1
6. Dodd P.J., Sismanidis C., Seddon J.A. Global burden of drug-resistant tuberculosis in children: a mathematical modelling study // Lancet Infect. Dis. – 2016. – Vol. 16, № 10. – P. 1193-1201. DOI: 10.1016/S1473-3099(16)30132-3
7. WHO consolidated guidelines on tuberculosis: Module 1: Tuberculosis preventive treatment. – Geneva: World Health Organization, 2020. Режим доступа: https://apps.who.int/iris/bitstream/handle/10665/331170/9789240001503-eng
8. WHO operational handbook on tuberculosis. Module 5: management of tuberculosis in children and adolescents. – Geneva: World Health Organization, 2022. Режим доступа: https://www.who.int/publications/i/item/9789240046832
Review
For citations:
Nikishova E.I., Guryeva T.I., Vlasova N.A., Markova A.A., Jafarova Z.E., Maryandyshev A.O. Treatment of active and latent multidrug-resistant tuberculosis in children of the same family. Tuberculosis and socially significant diseases. 2024;12(1):56-60. (In Russ.) https://doi.org/10.54921/2413-0346-2024-12-1-56-60
Views:
141
Email this article 