Sensitivity of the test with the tuberculosis allergen, containing recombinant protein ESAT6-CFP10, in new cases of tuberculosis in children and adolescents in Moscow.
Abstract
In Moscow in 2012, 521 children and adolescents were identified with tuberculosis (58,2% – Moscow citizens, 41.8% – migrants). We studied the way and details of the TB detection, the ratio of positive and negative Mantoux test and with recombinant tuberculosis allergen (ATP) of the patients, assessed the possible causes of adverse reactions.
Most of children, including the migrants, who were detected by mass tuberculin testing followed by skin test with the ATP. However, the number immigrants with TB, who were identified this way, more than permanent Moscow citizens (79.4 and 65.7%, respectively, p<0.001). Among adolescents, unlike children, a great number of patient with TB were identified while seeking for medical help (mostly as in-patients): 20.7% vs 1.7%. The high sensitivity of the skin test with ATP in children and adolescents (96.5% overall, 95%CI 94.5%, 97.8%), corresponds to the sensitivity of the Mantoux test. The negative results of tests with the ATP marked by a massive infection in infants, in immunocompromised persons and also in cases where the processes already identified in the phase of an involution (calcification) and during complications of the BCG vaccination.
About the Authors
L. V. Slogotskaya
ГКУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения города Москвы»; ГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава России, кафедра фтизиатрии
Russian Federation
Russian Federation
O. Yu. Sentchichina
ГКУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
E. M. Bogorodskaya
ГКУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения города Москвы»; ГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава России, кафедра фтизиатрии
Russian Federation
Russian Federation
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Review
For citations:
Slogotskaya L.V., Sentchichina O.Yu., Bogorodskaya E.M. Sensitivity of the test with the tuberculosis allergen, containing recombinant protein ESAT6-CFP10, in new cases of tuberculosis in children and adolescents in Moscow. Tuberculosis and socially significant diseases. 2013;(1):37-44. (In Russ.)
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