Adverse drug reactions during treatment of tuberculosis: the main questions
Abstract
The combined chemotherapy remains the main strategy of antituberculosis treatment. Current therapeutic regimens are associated to a high rate of adverse effects that can lead to therapeutic failure and worse prognosis. The review contains the recent data about classification, pathogenesis and clinical features of adverse reactions to anti-tuberculosis drugs. The universal strategy to prevent adverse reactions is presented. It based on individual risk assessment with subsequent choose of antituberculosis regimen, monitoring scheme and preventing drug prescriptions. The main problems in management of developed adverse reactions are reviewed, included methods of causality assessment, indications to withdrawal of antituberculosis drugs and symptomatic treatment.
About the Author
D. A. Ivanova
КУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения г. Москвы»
Russian Federation
Russian Federation
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Review
For citations:
Ivanova D.A. Adverse drug reactions during treatment of tuberculosis: the main questions. Tuberculosis and socially significant diseases. 2013;(1):57-65. (In Russ.)
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