INDICATORS OF PROCALCITONIN AND SOME PROINFLAMMATORY CYTOKINES PRODUCTION IN SEVERE TUBERCULOUS INFECTION IN CHILDREN AND ADOLESCENTS
Abstract
The preliminary results of the use of semi-quantitative immunoassay method (BRAHMSPCT-Q) for rapid diagnosis of procalcitonin level in 35 children and adolescents with severe tuberculosis are presented. Positive result of the procalcitonin test (more than 0,5 ng/ml) has been obtained in 12 patients, and negative one (less than 0,5 ng / ml) – in 23. Positive test result indicates high activity of mycobacterial population, confirmed by the detection of mycobacteria using three methods in such patients: fluorescent microscopy, cultural method on BACTEC and PCR diagnostics(83,3%, 100% and 83,3%, respectively) in contrast to the group of patients with negative test result (17,4%, 34,8% and 47,8%, respectively). In the patients with positive procalcitonin test, reliably greater production of some proinflammatory cytokines, MIF, TNF-α and IFN-γ, has been revealed.
About the Authors
M. M. Averbakh
ФГБУ «Центральный НИИ туберкулёза» РАМН, г. Москва
Russian Federation
Russian Federation
L. V. Panova
ФГБУ «Центральный НИИ туберкулёза» РАМН, г. Москва
Russian Federation
Russian Federation
M. F. Gubkina
ФГБУ «Центральный НИИ туберкулёза» РАМН, г. Москва
Russian Federation
Russian Federation
E. S. Ovsyankina
ФГБУ «Центральный НИИ туберкулёза» РАМН, г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Averbakh M.M., Panova L.V., Gubkina M.F., Ovsyankina E.S. INDICATORS OF PROCALCITONIN AND SOME PROINFLAMMATORY CYTOKINES PRODUCTION IN SEVERE TUBERCULOUS INFECTION IN CHILDREN AND ADOLESCENTS. Tuberculosis and socially significant diseases. 2013;(2):16-19. (In Russ.)
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