TO THE MECHAMISNS OF REGULATION OF TIBERCULOSIS INFLAMMATION
Abstract
The present study reviewed the role of one of the mechanisms of regulation of tuberculous inflammation, namely, a signal transmitted through the receptor (IFNAR1) for type I interferons in the course of experimental tuberculosis in mice. On the basis of studying of the characteristics of the course of TB in wild-type mice of 129S2 line and Ifnar1-/- mice on the same genetic basis we have shown that the signal transmitted through the IFNAR1-receptor worsens the course of experimental tuberculosis; It don’t prevent the proliferation of Mycobacterium tuberculosis in the lungs; It has no impact on the formation of an immune response to the BCG vaccine; It enhances the influx of neutrophils into the lungs with the redistribution of mycobacteria in these cellular elements; It serves to the accelerated development of the pathology and death of infected mice.
About the Authors
V. Ya. Herhert
ФГБНУ «Центральный научно-исследовательский институт туберкулеза»
Russian Federation
Russian Federation
V. V. Eremeev
ФГБНУ «Центральный научно-исследовательский институт туберкулеза»
Russian Federation
Russian Federation
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Review
For citations:
Herhert V.Ya., Eremeev V.V. TO THE MECHAMISNS OF REGULATION OF TIBERCULOSIS INFLAMMATION. Tuberculosis and socially significant diseases. 2016;(2):54-58. (In Russ.)
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