Latent tuberculosis infection in the adult risk groups in Moscow city, 2012–2016

Abstract

For latent tuberculosis (TB) infection (LTI) identification in risk groups of the adult population and detection the new TB cases of these patients in 2012–2016 in Moscow were performed 338 165 skin tests with allergen tuberculosis recombinant (ATR), 1136 T-SPOT®. TB tests and 702 – QuantiFERON®-ТВ Gold. The highest LTI rate was obtained in cured TB patients, at the moment of their transfer in the III group of supervision in TB dispensaries (just after the completed course of treatment) or after the completion of the following-up by TB physicians (21.1–22.9%). The next position belong to the individuals in difficult life situation (homeless and other social disadvantage persons) (9.3–10.5%) and TB contacts (5.6–6.1%). The new risk group was identified – adults from the inner circle of children with
positive skin test with ATR (LTI rate 18.4–20.8%). The LTI prevalence in Moscow’s employed population is less than 1.2% (e.g. in mandatory screened for TB employers – 0.8–1.2%, in adults from the inner circle of pregnant – 0.3–1.0%). The new TB cases detection per 1000 persons with LTI amounted to 3.2 in TB contacts, 14.7 – in mandatory screened for TB employers, 28.7 – in adults from the inner circle of children with positive skin test with ATR, 135.7 – in cured TB patients (after the completed course of treatment), 192.6 – in individuals in difficult life situation. So, in the relatively favorable TB situation in Moscow, ATR skin test can limit the TB risk groups.