COVID-19 in Tuberculosis Patients: Single Сare Center Experience
Abstract
Little is known about the relationship between the COVID-19 and tuberculosis (TB). The aim of this study is to describe a group of patients who died with TB (active disease or sequelae) and COVID-19. Data from 215 hospitalized patients with TB and COVID-19 were analyzed. Demographic and clinical variables were retrospectively collected, including co-morbidities and risk factors for TB and COVID-19 mortality. The median age of the cases was 43 years, and the male/female ratio was 2.5/1.0. Out of 215 patients 131 (60.9%) were migrants and 32 (14.9%) were homeless. Overall, 22 out of 215 (10.2%) patients died. All of them had 81 concomitant diseases, i.e. 2.8 per patient. Mortality rate was higher in intensive care unit (ICU) than hospital at all was three times higher than in the clinic as a whole: 29.6% vs 10.2% (p < 0.05). The highest rates were among patients aged over 60 (23.3%) vs patients aged 18 to 60 (8.1%) (p < 0,05). Active tuberculosis diagnosed in 20 (90.9%) of died patients, sequelae – in 2 (9.1%). The main cause of mortality was COVID-19 (11 cases – 50.0%), HIV – in 5 (22.7%) cases, TB – in 4 (18.2%), other diseases – in 2 (9.1%). The study findings show that susceptibility of tuberculosis patients to SARS-CoV-2 is most typical in age from 18 until 60 years (86.0%), in men mostly (71.2%). Almost every third case (29.8%) of COVID-19/TB co-infection occurs in HIV+ patients. 29.6% of patients with combined SARS-CoV-2/TB infection need treatment in ICU. 8.8% of patients underwent surgery.
About the Authors
O. N. O.N. Zuban
ГБУ3 города Москвы «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
M. N. Reshetnikov
ГБУ3 города Москвы «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
A. V. Ustinov
ГБУ3 города Москвы «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
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Review
For citations:
O.N. Zuban O.N., Reshetnikov M.N., Ustinov A.V. COVID-19 in Tuberculosis Patients: Single Сare Center Experience. Tuberculosis and socially significant diseases. 2020;(4):58-63. (In Russ.)
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