The possibility of questioning of tuberculosis patients in the control of unwanted side reactions

Abstract

In order to identify unwanted adverse reactions (ADRs) to antituberculosis drugs, using original questionnaires, a voluntary questionnaire was conducted among 40 patients with respiratory tuberculosis and 42 patients with HIV-infection and tuberculosis concomitant pathology. In both groups, most patients were treated according to IV and V chemotherapy regimens, in the group of patients with TOD – 72.5% and in the group of patients with HIV/TB – 71.4%. A total of 965 undesirable side reactions were recorded; the minimum number of undesirable side reactions in one patient is 0, the maximum is 40. In patients in the TOD group, the most frequently observed ADRs were from the central nervous system and sensory organs, the gastrointestinal tract and the musculoskeletal system. In patients in the HIV/TB group, ADRs of the central nervous system and sensory organs, the gastrointestinal tract and the immune system prevailed. In the group of patients with TOD, adverse reactions with a moderate degree of severity were most often noted, in the group of patients with HIV/TB – with a mild degree of severity. According to the severity of ADRs, significant differences were established only when comparing the total number of reactions in both groups of patients.