COMPARATIVE RESULTS OF SKIN TESTING USING TUBERCULOSIS ALLERGEN RECOMBINANT AND QUANTIFERON–GIT IN CHILDREN AND ADOLESCENTS WITH TB INFECTION
Abstract
Aim: to compare results of skin testing using the preparation CFP-10-ESAT-6 (DST) and QuantiFERON – GIT (QFT) in children and adolescents with local TB or latent TB infection (LTBI). 210 children and adolescents were studied including 163 (77,6%) with TB and 47 (22,4%) with LTBI. All the children received chemotherapy for at least 2 months for LTBI and 6 months for active TB. Positive DST was observed in 172 (81,9%, 95%CI 76,1-86,6%) including 90,7% in TB-patients and 51,1% in LTBI, р<0,001. Positive QFT-GIT was registered in 176 (83,8%, 95%CI 78,2-88,2%) subjects including 92,6% in TB-patients and 53,2% in LTBI, р<0,001. Agreement of DST and QFT-GIT was 90,5% (95%CI 85,7-93,8%), kappa coefficient was 0,67±0,07 (р<0,001). Discordance was registered in 20 (9,5%) cases. 11 patients with negative DST reactions have positive QFT results. Among them 9 patients initially had positive DST – reactions and after chemotherapy reaction became negative. Probably DST reversion in these children as a result of chemotherapy pass ahead of reversion QFT results. This determined the discordant reactions.
About the Authors
L. V. Slogotskaya
ГКУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
D. F. Ivanova
ГКУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
O. Yu. Senchihina
Russian Federation
M. V. Makarova
Russian Federation
O. I. Aleschenkova
ГКУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
N. V. Kulikovsraya
ГКУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
T. V. Vaneeva
ГКУЗ «Московский городской научно-практический центр борьбы с туберкулёзом Департамента здравоохранения города Москвы»
Russian Federation
Russian Federation
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Review
For citations:
Slogotskaya L.V., Ivanova D.F., Senchihina O.Yu., Makarova M.V., Aleschenkova O.I., Kulikovsraya N.V., Vaneeva T.V. COMPARATIVE RESULTS OF SKIN TESTING USING TUBERCULOSIS ALLERGEN RECOMBINANT AND QUANTIFERON–GIT IN CHILDREN AND ADOLESCENTS WITH TB INFECTION. Tuberculosis and socially significant diseases. 2013;(2):45-51. (In Russ.)
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