THE BACTERIAL BURDEN OF THE RESPIRATORY AND OPERATIVE SAMPLES FROM PATIENTS WITH DRUG-SENSITIVE, MULTIDRUGRESISTANT AND EXTENSIVELY DRUG-RESISTANT PULMONARY TUBERCULOSIS
Abstract
It were investigated the drug sensitivity (DS) of Mycobacterium tuberculosis (Mtb) and the bacterial burden of respiratory (RS) and surgery (OS) samples derived from previously treated patients (clinics of SPb Institute for Phthisiopulmonology, 2010-2014): I group – patients without surgery treatment (153 strains), II – operated patients, mainly with chronic and hyperchronic disease (546 strains), III – reference group, non-operated patients with MTB DS (79 strains). It was found that the growth properties of MTB with MDR and XDR have no differences with the growth properties of MTB with drug sensitivity. The known regularity was confirmed that in the cases of MDR the frequency of MTB burden in RS is much higher than in OS – 63.7% vs 41,9%. In OS high and medium degree of MTB burden in the cases of XDR was observed much more frequently than in MDR cases – totally 71.7% vs 53.7%. Persons with the high degree of MTB burden in RS had dominated in the group of operated patients. This confirms that the high viability of MTB is retained both in MDR cases as in XDR cases.
About the Authors
B. I. Vishnevskiy
ФГБУ «Санкт-Петербургский НИИ фтизиопульмонологии Минздрава России»
Russian Federation
Russian Federation
O. A. Manicheva
ФГБУ «Санкт-Петербургский НИИ фтизиопульмонологии Минздрава России»
Russian Federation
Russian Federation
N. N. Melnikova
ФГБУ «Санкт-Петербургский НИИ фтизиопульмонологии Минздрава России»
Russian Federation
Russian Federation
M. Z. Dogonadze
ФГБУ «Санкт-Петербургский НИИ фтизиопульмонологии Минздрава России»
Russian Federation
Russian Federation
L. N. Steklova
ФГБУ «Санкт-Петербургский НИИ фтизиопульмонологии Минздрава России»
Russian Federation
Russian Federation
A. I. Inozemtseva
ФГБУ «Санкт-Петербургский НИИ фтизиопульмонологии Минздрава России»
Russian Federation
Russian Federation
References
1. Бухарин О.В., Гинцбург А.Л., Романова Ю.М., Эль-Регистан Г.И. Механизмы выживания бактерий / под ред. О.В. Бухарина // М.: Медицина. – 2005. – 364 с.
2. Вишневский Б.И., Маничева О.А, Вишневская Е.Б., Мельникова Н.Н., Оттен Т.Ф. Особенности бактериовыделения и лекарственной устойчивости микобактерий туберкулеза при внелегочном туберкулезе. // Проблемы туберкулеза и болезней легких. – 2006. – № 11. – С. 18-21.
3. Прозоров А.А., Даниленко В.Н. Микобактерии туберкулезного комплекса: геномика, молекулярная эпидемиология, пути эволюции. // Успехи современной биологии. – 2011. – № 3. – С. 227-243.
4. Тестов В.В., Стерликов С.А., Васильева И.А. и др. Результаты химиотерапии у больных туберкулезом с множественной лекарственной устойчивостью возбудителя в регионах Российской Федерации. // Туберкулез и болезни легких. – 2014. – № 4. – С. 9-14.
5. Casali N., Nikolaevsky V., Balabanova Y. et.al. Evolution and transmission of drug-resistant tuberculosis in a Russian population. // Nat. Genet. – 2014. – Vol. 46 – N. 3. – P. 279-286.
6. Cohen T., Becerra M., Murray M. Isoniazid resistance and the future of drug-resistant tuberculosis. // Microb. Drug. Resist. – 2004. – Vol. 10. – N. 4. – P. 280-285.
7. Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs. // Ann. Pharmacother. – 2006. – Vol. 40. – N. 5. – P. 1007-1008.
8. Yablonskii P., Vizel A., Galkin V., Shulgina M. Tuberculosis in Russia. Its history and its status today // Am. J. Respir. Crit. Care Med. – 2015. – Vol. 191. – N. 4. – P. 372-376.
Review
For citations:
Vishnevskiy B.I., Manicheva O.A., Melnikova N.N., Dogonadze M.Z., Steklova L.N., Inozemtseva A.I. THE BACTERIAL BURDEN OF THE RESPIRATORY AND OPERATIVE SAMPLES FROM PATIENTS WITH DRUG-SENSITIVE, MULTIDRUGRESISTANT AND EXTENSIVELY DRUG-RESISTANT PULMONARY TUBERCULOSIS. Tuberculosis and socially significant diseases. 2016;(2):44-48. (In Russ.)
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